Potential viral pathogenic mechanism in human type 1 diabetes

In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 + T cells, together with a significant number of other inflammatory cells, including CD8 + T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-pro...

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Vydané v:Diabetologia Ročník 57; číslo 10; s. 2009 - 2018
Hlavní autori: Schneider, Darius A., von Herrath, Matthias G.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2014
Springer
Springer Nature B.V
Predmet:
Antigens
Autoimmunity - immunology
Biological and medical sciences
CD8-Positive T-Lymphocytes - immunology
Diabetes
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - virology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Human Physiology
Humans
Inflammation
Internal Medicine
Lymphocytes
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Pancreas
Pathogenesis
Review
Viral infections
Virus Diseases - complications
Virus Diseases - immunology
La Jolla California
United States > US
Insulitis
Type 1 diabetes
Humans
Viruses
Autoimmune
Enterovirus
Environmental factors
Endocrinopathy
Autoimmunity
Human
Immunopathology
Picornaviridae
Autoimmune disease
Environmental factor
Virus
ISSN:0012-186X, 1432-0428, 1432-0428
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Abstract In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 + T cells, together with a significant number of other inflammatory cells, including CD8 + T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells. Type 1 diabetes is a multifactorial disease caused by an interactive combination of genetic and environmental factors. Viruses are major environmental candidates with known potential effects on specific key points in the pathogenesis of type 1 diabetes and recent findings seem to confirm this presumption. However, we still lack well-grounded mechanistic explanations for how exactly viruses may influence type 1 diabetes aetiology. In this review we provide a summary of experimentally defined viral mechanisms potentially involved in the ontology of type 1 diabetes and discuss some novel hypotheses of how viruses may affect the initiation and natural history of the disease.
AbstractList In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8(+) T cells, together with a significant number of other inflammatory cells, including CD8(+) T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells. Type 1 diabetes is a multifactorial disease caused by an interactive combination of genetic and environmental factors. Viruses are major environmental candidates with known potential effects on specific key points in the pathogenesis of type 1 diabetes and recent findings seem to confirm this presumption. However, we still lack well-grounded mechanistic explanations for how exactly viruses may influence type 1 diabetes aetiology. In this review we provide a summary of experimentally defined viral mechanisms potentially involved in the ontology of type 1 diabetes and discuss some novel hypotheses of how viruses may affect the initiation and natural history of the disease.In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8(+) T cells, together with a significant number of other inflammatory cells, including CD8(+) T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells. Type 1 diabetes is a multifactorial disease caused by an interactive combination of genetic and environmental factors. Viruses are major environmental candidates with known potential effects on specific key points in the pathogenesis of type 1 diabetes and recent findings seem to confirm this presumption. However, we still lack well-grounded mechanistic explanations for how exactly viruses may influence type 1 diabetes aetiology. In this review we provide a summary of experimentally defined viral mechanisms potentially involved in the ontology of type 1 diabetes and discuss some novel hypotheses of how viruses may affect the initiation and natural history of the disease.
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 super(+) T cells, together with a significant number of other inflammatory cells, including CD8 super(+) T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells. Type 1 diabetes is a multifactorial disease caused by an interactive combination of genetic and environmental factors. Viruses are major environmental candidates with known potential effects on specific key points in the pathogenesis of type 1 diabetes and recent findings seem to confirm this presumption. However, we still lack well-grounded mechanistic explanations for how exactly viruses may influence type 1 diabetes aetiology. In this review we provide a summary of experimentally defined viral mechanisms potentially involved in the ontology of type 1 diabetes and discuss some novel hypotheses of how viruses may affect the initiation and natural history of the disease.
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8^sup +^ T cells, together with a significant number of other inflammatory cells, including CD8^sup +^ T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells. Type 1 diabetes is a multifactorial disease caused by an interactive combination of genetic and environmental factors. Viruses are major environmental candidates with known potential effects on specific key points in the pathogenesis of type 1 diabetes and recent findings seem to confirm this presumption. However, we still lack well-grounded mechanistic explanations for how exactly viruses may influence type 1 diabetes aetiology. In this review we provide a summary of experimentally defined viral mechanisms potentially involved in the ontology of type 1 diabetes and discuss some novel hypotheses of how viruses may affect the initiation and natural history of the disease.[PUBLICATION ABSTRACT]
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8+ T cells, together with a significant number of other inflammatory cells, including CD8+ T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells. Type 1 diabetes is a multifactorial disease caused by an interactive combination of genetic and environmental factors. Viruses are major environmental candidates with known potential effects on specific key points in the pathogenesis of type 1 diabetes and recent findings seem to confirm this presumption. However, we still lack well-grounded mechanistic explanations for how exactly viruses may influence type 1 diabetes aetiology. In this review we provide a summary of experimentally defined viral mechanisms potentially involved in the ontology of type 1 diabetes and discuss some novel hypotheses of how viruses may affect the initiation and natural history of the disease.
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 + T cells, together with a significant number of other inflammatory cells, including CD8 + T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells. Type 1 diabetes is a multifactorial disease caused by an interactive combination of genetic and environmental factors. Viruses are major environmental candidates with known potential effects on specific key points in the pathogenesis of type 1 diabetes and recent findings seem to confirm this presumption. However, we still lack well-grounded mechanistic explanations for how exactly viruses may influence type 1 diabetes aetiology. In this review we provide a summary of experimentally defined viral mechanisms potentially involved in the ontology of type 1 diabetes and discuss some novel hypotheses of how viruses may affect the initiation and natural history of the disease.
Author Schneider, Darius A.
von Herrath, Matthias G.
Author_xml – sequence: 1
  givenname: Darius A.
  surname: Schneider
  fullname: Schneider, Darius A.
  organization: La Jolla Institute for Allergy and Immunology, Department of Medicine, UC San Diego
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  givenname: Matthias G.
  surname: von Herrath
  fullname: von Herrath, Matthias G.
  email: Matthias@liai.org
  organization: La Jolla Institute for Allergy and Immunology, Novo Nordisk Type 1 Diabetes Research Center
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2015 INIST-CNRS
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IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Keywords Insulitis
Type 1 diabetes
Humans
Viruses
Autoimmune
Enterovirus
Environmental factors
Endocrinopathy
Autoimmunity
Human
Immunopathology
Picornaviridae
Autoimmune disease
Environmental factor
Virus
Language English
License CC BY 4.0
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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PublicationDate 2014-10-01
PublicationDateYYYYMMDD 2014-10-01
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PublicationSubtitle Clinical and Experimental Diabetes and Metabolism
PublicationTitle Diabetologia
PublicationTitleAbbrev Diabetologia
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PublicationYear 2014
Publisher Springer Berlin Heidelberg
Springer
Springer Nature B.V
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Snippet In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 + T cells, together with a significant number of other inflammatory...
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8(+) T cells, together with a significant number of other inflammatory...
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8^sup +^ T cells, together with a significant number of other...
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8 super(+) T cells, together with a significant number of other...
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8+ T cells, together with a significant number of other inflammatory...
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SourceType Open Access Repository
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StartPage 2009
SubjectTerms Antigens
Autoimmunity - immunology
Biological and medical sciences
CD8-Positive T-Lymphocytes - immunology
Diabetes
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - virology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Human Physiology
Humans
Inflammation
Internal Medicine
Lymphocytes
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Pancreas
Pathogenesis
Review
Viral infections
Virus Diseases - complications
Virus Diseases - immunology
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Title Potential viral pathogenic mechanism in human type 1 diabetes
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