miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes

Background. The use of miRNAs as biomarkers for Type 1 Diabetes (T1D) risk is attractive as T1D is usually diagnosed in front of acute symptoms. As miR-375 is highly expressed in the endocrine pancreas, we postulated that its circulating level might reflect beta cell alterations and might be altered...

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Vydáno v:	Journal of Diabetes Research Ročník 2016; číslo 2016; s. 1 - 7
Hlavní autoři:	Rome, Sophie, Thivolet, Charles, Nicolino, Marc, Fabien, Nicole, Van den Hende, Kathleen, Meugnier, Emmanuelle, Jalabert, Audrey, Marchand, Lucien, Madec, Anne-Marie
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cairo, Egypt Hindawi Publishing Corporation 01.01.2016 John Wiley & Sons, Inc Hindawi Publishing Coporation Wiley
Témata:	Adolescent Age Autoantibodies Autoimmunity Biomarkers Child Dextrose Diabetes Diabetes Mellitus, Type 1 - blood Diabetes therapy Disease Down-Regulation - drug effects Female Gender Gene expression Glucose Glucose - pharmacology Glycosylated hemoglobin Humans Insulin Islets of Langerhans - drug effects Islets of Langerhans - metabolism Life Sciences Male Metabolism MicroRNA MicroRNAs - blood Pancreas Pediatrics Sensors Software Type 1 diabetes Type 2 diabetes France micrornas disease nod mice autoimmune mir-375 biomarkers responses mechanism strategy beta-cell mass
ISSN:	2314-6745, 2314-6753, 2314-6753
On-line přístup:	Získat plný text
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