Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims

Teenage suicide is a major public health concern, but its neurobiology is not well understood. Proinflammatory cytokines play an important role in stress and in the pathophysiology of depression—two major risk factors for suicide. Cytokines are increased in the serum of patients with depression and...

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Vydáno v:	Journal of psychiatric research Ročník 46; číslo 1; s. 57 - 63
Hlavní autoři:	Pandey, Ghanshyam N., Rizavi, Hooriyah S., Ren, Xinguo, Fareed, Jawed, Hoppensteadt, Debra A., Roberts, Rosalinda C., Conley, Robert R., Dwivedi, Yogesh
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Kidlington Elsevier Ltd 01.01.2012 Elsevier
Témata:	Adolescent Adult and adolescent clinical studies Biological and medical sciences Child Cortex Cytokines Cytokines - genetics Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Female Gene Expression Regulation - physiology Humans IL-1β IL-6 Male Medical sciences Pathophysiological aspects Postmortem brain Postmortem Changes Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Proteins Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry RNA, Messenger - metabolism Suicidal behaviour Suicide Teenage suicide TNF-α Victims Young Adult Teenage suicide Cytokines TNF-α IL-1β Postmortem brain IL-6 Central nervous system Cytokine Postmortem Interleukin 1β Inflammation Prefrontal cortex Suicide Encephalon Interleukin 6 Tumor necrosis factor α Victim
ISSN:	0022-3956, 1879-1379, 1879-1379
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Shrnutí:	Teenage suicide is a major public health concern, but its neurobiology is not well understood. Proinflammatory cytokines play an important role in stress and in the pathophysiology of depression—two major risk factors for suicide. Cytokines are increased in the serum of patients with depression and suicidal behavior; however, it is not clear if similar abnormality in cytokines occurs in brains of suicide victims. We therefore measured the gene and protein expression levels of proinflammatory cytokines interleukin (IL)-1β, IL-6, and tissue necrosis factor (TNF)-α in the prefrontal cortex (PFC) of 24 teenage suicide victims and 24 matched normal control subjects. Our results show that the mRNA and protein expression levels of IL-1β, IL-6, and TNF-α were significantly increased in Brodmann area 10 (BA-10) of suicide victims compared with normal control subjects. These results suggest an important role for IL-1β, IL-6, and TNF-α in the pathophysiology of suicidal behavior and that proinflammatory cytokines may be an appropriate target for developing therapeutic agents.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-3956 1879-1379 1879-1379
DOI:	10.1016/j.jpsychires.2011.08.006