Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims

Teenage suicide is a major public health concern, but its neurobiology is not well understood. Proinflammatory cytokines play an important role in stress and in the pathophysiology of depression—two major risk factors for suicide. Cytokines are increased in the serum of patients with depression and...

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Bibliographic Details
Published in:Journal of psychiatric research Vol. 46; no. 1; pp. 57 - 63
Main Authors: Pandey, Ghanshyam N., Rizavi, Hooriyah S., Ren, Xinguo, Fareed, Jawed, Hoppensteadt, Debra A., Roberts, Rosalinda C., Conley, Robert R., Dwivedi, Yogesh
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01.01.2012
Elsevier
Subjects:
Adolescent
Adult and adolescent clinical studies
Biological and medical sciences
Child
Cortex
Cytokines
Cytokines - genetics
Cytokines - metabolism
Enzyme-Linked Immunosorbent Assay
Female
Gene Expression Regulation - physiology
Humans
IL-1β
IL-6
Male
Medical sciences
Pathophysiological aspects
Postmortem brain
Postmortem Changes
Prefrontal Cortex - metabolism
Prefrontal Cortex - pathology
Proteins
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
RNA, Messenger - metabolism
Suicidal behaviour
Suicide
Teenage suicide
TNF-α
Victims
Young Adult
Teenage suicide
Cytokines
TNF-α
IL-1β
Postmortem brain
IL-6
Central nervous system
Cytokine
Postmortem
Interleukin 1β
Inflammation
Prefrontal cortex
Suicide
Encephalon
Interleukin 6
Tumor necrosis factor α
Victim
ISSN:0022-3956, 1879-1379, 1879-1379
Online Access:Get full text
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Summary:Teenage suicide is a major public health concern, but its neurobiology is not well understood. Proinflammatory cytokines play an important role in stress and in the pathophysiology of depression—two major risk factors for suicide. Cytokines are increased in the serum of patients with depression and suicidal behavior; however, it is not clear if similar abnormality in cytokines occurs in brains of suicide victims. We therefore measured the gene and protein expression levels of proinflammatory cytokines interleukin (IL)-1β, IL-6, and tissue necrosis factor (TNF)-α in the prefrontal cortex (PFC) of 24 teenage suicide victims and 24 matched normal control subjects. Our results show that the mRNA and protein expression levels of IL-1β, IL-6, and TNF-α were significantly increased in Brodmann area 10 (BA-10) of suicide victims compared with normal control subjects. These results suggest an important role for IL-1β, IL-6, and TNF-α in the pathophysiology of suicidal behavior and that proinflammatory cytokines may be an appropriate target for developing therapeutic agents.
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ISSN:0022-3956
1879-1379
1879-1379
DOI:10.1016/j.jpsychires.2011.08.006