Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction...

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Vydané v:	Immunity & ageing Ročník 17; číslo 1; s. 2 - 17
Hlavní autori:	Thomas, Rachel, Wang, Weikan, Su, Dong-Ming
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 20.01.2020 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Adaptive immunity Age Age-related thymic involution Aging Antibodies Antigens Apoptosis Atrophy Biomedical and Life Sciences Biomedicine Cardiovascular diseases Cell cycle Central tolerance Clinical Nutrition Cyclin-dependent kinases Diseases Epigenetic inheritance Epigenetics Fibroblasts Genotype & phenotype Geriatrics/Gerontology Homeostasis Immune response Immune system Immunology Immunosenescence Immunosenescence and inflammaging Inflammation Kinases Lymphocytes Lymphocytes T Molecular modelling Money Negative selection and regulatory T (Treg) cell generation Phenotypes Public Health Recovery of function Rejuvenation Review Senescence Somatic cells Stem cells T cells Thymic aging Thymic involution Thymus Maryland Negative selection and regulatory T (Treg) cell generation Central tolerance Thymic aging Age-related thymic involution Immunosenescence and inflammaging Rejuvenation
ISSN:	1742-4933, 1742-4933
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