Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenescence refers to disruption in the structural architecture of immune organs and dysfunction...

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Veröffentlicht in:	Immunity & ageing Jg. 17; H. 1; S. 2 - 17
Hauptverfasser:	Thomas, Rachel, Wang, Weikan, Su, Dong-Ming
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 20.01.2020 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Adaptive immunity Age Age-related thymic involution Aging Antibodies Antigens Apoptosis Atrophy Biomedical and Life Sciences Biomedicine Cardiovascular diseases Cell cycle Central tolerance Clinical Nutrition Cyclin-dependent kinases Diseases Epigenetic inheritance Epigenetics Fibroblasts Genotype & phenotype Geriatrics/Gerontology Homeostasis Immune response Immune system Immunology Immunosenescence Immunosenescence and inflammaging Inflammation Kinases Lymphocytes Lymphocytes T Molecular modelling Money Negative selection and regulatory T (Treg) cell generation Phenotypes Public Health Recovery of function Rejuvenation Review Senescence Somatic cells Stem cells T cells Thymic aging Thymic involution Thymus Maryland Negative selection and regulatory T (Treg) cell generation Central tolerance Thymic aging Age-related thymic involution Immunosenescence and inflammaging Rejuvenation
ISSN:	1742-4933, 1742-4933
Online-Zugang:	Volltext
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