Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia

Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 pa...

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Published in:	PloS one Vol. 16; no. 6; p. e0252939
Main Authors:	Araya, Shambel, Mamo, Mintesnot Aragaw, Tsegay, Yakob Gebregziabher, Atlaw, Asegdew, Aytenew, Aschalew, Hordofa, Abebe, Negeso, Abebe Edao, Wordofa, Moges, Niguse, Tirhas, Cheru, Mahlet, Tamir, Zemenu
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 21.06.2021 Public Library of Science (PLoS)
Subjects:	Abnormalities Biology and Life Sciences Biotechnology Blood Blood clotting Blood coagulation Coagulation Computer programs Corona Coronaviruses COVID-19 Data analysis Drafting software Editing Ethics Funding Health sciences Health services Infections Medical laboratories Medical prognosis Medical research Medical schools Medicine and Health Sciences Methodology Parameters Patients People and Places Polymerase chain reaction R&D Research & development Research ethics Respiratory distress syndrome Risk factors Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sociodemographics Software Statistical analysis Supervision Values Viral diseases Viruses Visualization Ethiopia Addis Ababa Ethiopia
ISSN:	1932-6203, 1932-6203
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Abstract	Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia. This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant. A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively. In this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients.
AbstractList	Background Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia. Methods This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant. Result A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively. Conclusion In this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients. Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia. This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant. A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively. In this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients. BackgroundCoagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia.MethodsThis prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant.ResultA prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively.ConclusionIn this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients. Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia.BACKGROUNDCoagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19 patients are important prognostic factors of disease severity. The aim of this study was to analyze coagulation profiles of hospitalized COVID-19 patients in Addis Ababa, Ethiopia.This prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant.METHODSThis prospective cross-sectional study was conducted among 455 Covid-19 patients admitted at Millennium COVID-19 care and treatment center, Addis Ababa, Ethiopia from July 1- October 23, 2020. Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and International normalized ratio (INR) were determined on HUMACLOT DUE PLUS® coagulation analyzer (Wiesbaden, Germany). In all statistical analysis of results, p<0.05 was defined as statistically significant.A prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively.RESULTA prolonged prothrombin time was found in 46.8% of study participants with COVID-19 and a prolonged prothrombin time and elevated INR in 53.3% of study subjects with severe and 51% of critically COVID patients. Thrombocytopenia was detected in 22.1% of COVID-19 patients. 50.5% and 51.3% of COVID-19 patients older than 55 years had thrombocytopenia and prolonged APTT respectively.In this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients.CONCLUSIONIn this study, prolonged prothrombin time and elevated INR were detected in more than 50% of severe and critical COVID-19 patients. Thrombocytopenia and prolonged APTT were dominant in COVID-19 patients older than 55 years. Thus, we recommend emphasis to be given for monitoring of platelet count, PT, APTT and INR in hospitalized and admitted COVID-19 patients. About the Authors: Shambel Araya Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing * E-mail: shambelaraya8@gmail.com Affiliations Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia, Department of Medical Laboratory, Millennium COVID-19 Treatment and Care Centre, St. Paual Millennium Medical College, Addis Ababa, Ethiopia ORCID logo https://orcid.org/0000-0002-0109-6062 Mintesnot Aragaw Mamo Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing Affiliations Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia, Department of Medical Laboratory, Millennium COVID-19 Treatment and Care Centre, St. Paual Millennium Medical College, Addis Ababa, Ethiopia Yakob Gebregziabher Tsegay Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing Affiliations Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia, Department of Research and Development Center, College of Health Sciences, Defense University, Addis Ababa, Ethiopia Asegdew Atlaw Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing Affiliation: Department of Medical Laboratory, Millennium COVID-19 Treatment and Care Centre, St. Paual Millennium Medical College, Addis Ababa, Ethiopia Aschalew Aytenew Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing Affiliation: Department of Medical Laboratory, Millennium COVID-19 Treatment and Care Centre, St. Paual Millennium Medical College, Addis Ababa, Ethiopia Abebe Hordofa Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing Affiliation: Department of Medical Laboratory, Millennium COVID-19 Treatment and Care Centre, St. Paual Millennium Medical College, Addis Ababa, Ethiopia Abebe Edao Negeso Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing Affiliation: Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia Moges Wordofa Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing Affiliation: Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia Tirhas Niguse Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing Affiliation: Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia Mahlet Cheru Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing Affiliation: Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia Zemenu Tamir Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing Affiliation: Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia Introduction Coronavirus disease 2019 (COVID-19) is caused by a novel beta corona virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1]. The result of blood coagulation profiles in COVID-19 patients can also guide management decisions and improve outcomes [12, 14]. [...]routine coagulation parameter tests results could potentially be utilized in symptomatic patients in resource limited settings with inadequate access to COVID-19 RT-PCR, as in Ethiopia, to raise suspension of this infection. [...]data on coagulation profiles among Ethiopian COVID-19 patients is not readily available. [...]the aim of this study was to determine the coagulation profile of COVID-19 patients admitted at Millennium COVID-19 treatment center, Addis Ababa, Ethiopia. Methods Ethical consideration Ethical clearance was obtained and approved by Addis Ababa University College of Health Sciences, department of Medical Laboratory Sciences research ethics review committee (DRERC/538/20/MLS) and it was in accordance with the principles of the Helsinki II declaration.
Audience	Academic
Author	Aytenew, Aschalew Niguse, Tirhas Wordofa, Moges Tsegay, Yakob Gebregziabher Araya, Shambel Atlaw, Asegdew Negeso, Abebe Edao Hordofa, Abebe Cheru, Mahlet Mamo, Mintesnot Aragaw Tamir, Zemenu
AuthorAffiliation	1 Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia University of Witwatersrand/NHLS, SOUTH AFRICA 4 Department of Research and Development Center, College of Health Sciences, Defense University, Addis Ababa, Ethiopia 2 Department of Medical Laboratory, Millennium COVID-19 Treatment and Care Centre, St. Paual Millennium Medical College, Addis Ababa, Ethiopia 3 Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia
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Cites_doi	10.26719/emhj.20.105 10.1016/j.amsu.2020.06.035 10.1007/s11739-020-02443-8 10.3390/jcm9113482 10.1007/s11239-020-02129-0 10.1016/j.ijsu.2020.02.034 10.5935/0103-507X.20200031 10.1016/S2352-3026(20)30145-9 10.5582/bst.2020.03086 10.5152/TurkThoracJ.2020.20067 10.1016/S2213-2600(20)30216-2 10.1056/NEJMoa2002032 10.1177/1076029620964868 10.1016/S2352-3026(20)30218-0 10.1016/j.ijid.2020.09.021 10.1016/j.thromres.2020.06.026 10.1016/j.thromres.2020.09.004 10.1182/blood.2020006520 10.1016/j.cca.2020.05.031 10.1182/bloodadvances.2020002197 10.1111/bjh.16725 10.1515/cclm-2020-0502 10.1186/s40164-020-00172-4 10.1155/2020/6159720 10.1007/s11239-020-02130-7
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References	M Quintana-Diaz (pone.0252939.ref014) 2020; 9 F Savioli (pone.0252939.ref038) 2020; 32 pone.0252939.ref015 C Bao (pone.0252939.ref032) 2020; 9 M Levi (pone.0252939.ref013); 4 G Kasinathan (pone.0252939.ref040) 2020; 56 WJ Guan (pone.0252939.ref004) 2020; 382 S Voicu (pone.0252939.ref030) 2020; 24 A Annunziata (pone.0252939.ref010) 2020; 21 V Pavoni (pone.0252939.ref037) 2020; 50 JC Song (pone.0252939.ref035) 2020; 7 FB Belen-Apak (pone.0252939.ref026); 50 M Xiong (pone.0252939.ref033) 2020; 189 RJ Jose (pone.0252939.ref039) 2020; 8 EH Adam (pone.0252939.ref024); 194 S Coccheri (pone.0252939.ref006) 2020; 15 T Kander (pone.0252939.ref034) 2020; 7 H Mei (pone.0252939.ref031) 2020; 41 NC Chan (pone.0252939.ref016) 2020; 41 pone.0252939.ref002 H Long (pone.0252939.ref003) 2020; 2020 F Savioli (pone.0252939.ref011) 2020; 32 A Zhang (pone.0252939.ref019) 2020; 100 A Rauch (pone.0252939.ref017) 2020 M Levi (pone.0252939.ref021) 2020; 7 AY Lee (pone.0252939.ref027) 2020 X Chen (pone.0252939.ref036) 2020; 26 H Al-Samkari (pone.0252939.ref009) 2020; 136 J Harenberg (pone.0252939.ref028) 2020; 58 C Sohrabi (pone.0252939.ref001) 2020; 76 R Pizzi (pone.0252939.ref029) 2020; 196 HC Luo (pone.0252939.ref020) 2020 A Parasher (pone.0252939.ref008) 2020 M Quintana-Díaz (pone.0252939.ref007) 2020; 9 M Aggarwal (pone.0252939.ref005); 2020 D Buioni (pone.0252939.ref012) 2020; 508 B Sayad (pone.0252939.ref023) 2020; 26 V Paar (pone.0252939.ref025) 2020 Y Zou (pone.0252939.ref022) 2020; 14 Y Zhang (pone.0252939.ref018) 2020
References_xml	– volume: 26 start-page: 999 issue: 9 year: 2020 ident: pone.0252939.ref023 article-title: Blood coagulation parameters in patients with severe COVID-19 from Kermanshah Province, Islamic Republic of Iran publication-title: East Mediterr Health J doi: 10.26719/emhj.20.105 – ident: pone.0252939.ref002 – volume: 56 start-page: 173 year: 2020 ident: pone.0252939.ref040 article-title: Haematological manifestations, mechanisms of thrombosis and anti-coagulation in COVID-19 disease: A review publication-title: Ann Med Surg (Lond). doi: 10.1016/j.amsu.2020.06.035 – volume: 15 start-page: 1369 issue: 8 year: 2020 ident: pone.0252939.ref006 article-title: COVID-19: The crucial role of blood coagulation and fibrinolysis. publication-title: Intern Emerg Med doi: 10.1007/s11739-020-02443-8 – volume: 9 issue: 11 year: 2020 ident: pone.0252939.ref014 article-title: Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with COVID-19. publication-title: J Clin Med. doi: 10.3390/jcm9113482 – volume: 24 start-page: 9161 issue: 17 year: 2020 ident: pone.0252939.ref030 article-title: Imbalance between procoagulant factors and natural coagulation inhibitors contributes to hypercoagulability in the critically ill COVID-19 patient: clinical implications. publication-title: Eur Rev Med Pharmacol Sci – volume: 50 start-page: 278 issue: 2 ident: pone.0252939.ref026 article-title: Pulmonary intravascular coagulation in COVID-19: possible pathogenesis and recommendations on anticoagulant/thrombolytic therapy. publication-title: J Thromb Thrombolysis. 2020 doi: 10.1007/s11239-020-02129-0 – year: 2020 ident: pone.0252939.ref027 publication-title: COVID-19 and Coagulopathy – volume: 76 start-page: 71 year: 2020 ident: pone.0252939.ref001 article-title: World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). publication-title: Int J Surg. doi: 10.1016/j.ijsu.2020.02.034 – volume: 32 issue: 2 year: 2020 ident: pone.0252939.ref011 article-title: Coagulation profile in severe COVID-19 patients: what do we know so far? publication-title: Revista Brasileira de Terapia Intensiva doi: 10.5935/0103-507X.20200031 – year: 2020 ident: pone.0252939.ref017 article-title: Coagulation biomarkers are independent predictors of increased oxygen requirements in COVID-19 publication-title: J Thromb Haemost – volume: 7 start-page: e438 issue: 6 year: 2020 ident: pone.0252939.ref021 article-title: Coagulation abnormalities and thrombosis in patients with COVID-19 publication-title: Lancet Haematol. doi: 10.1016/S2352-3026(20)30145-9 – volume: 32 start-page: 197 issue: 2 year: 2020 ident: pone.0252939.ref038 article-title: Coagulation profile in severe COVID-19 patients: what do we know so far? publication-title: Rev Bras Ter Intensiva doi: 10.5935/0103-507X.20200031 – ident: pone.0252939.ref015 – volume: 14 start-page: 285 issue: 4 year: 2020 ident: pone.0252939.ref022 article-title: Analysis of coagulation parameters in patients with COVID-19 in Shanghai, China. publication-title: Biosci Trends. doi: 10.5582/bst.2020.03086 – volume: 21 start-page: 287 issue: 4 year: 2020 ident: pone.0252939.ref010 article-title: Pulmonary Embolism in Covid-19: Coagulation Parameters, Close Monitoring to Prevent? publication-title: Turk Thorac J doi: 10.5152/TurkThoracJ.2020.20067 – volume: 8 start-page: e46 issue: 6 year: 2020 ident: pone.0252939.ref039 article-title: COVID-19 cytokine storm: the interplay between inflammation and coagulation publication-title: Lancet Respir Med. doi: 10.1016/S2213-2600(20)30216-2 – volume: 382 start-page: 1708 issue: 18 year: 2020 ident: pone.0252939.ref004 article-title: Clinical Characteristics of Coronavirus Disease 2019 in China publication-title: The New England journal of medicine doi: 10.1056/NEJMoa2002032 – volume: 26 start-page: 1076029620964868 year: 2020 ident: pone.0252939.ref036 article-title: A Retrospective Analysis of the Coagulation Dysfunction in COVID-19 Patients publication-title: Clin Appl Thromb Hemost doi: 10.1177/1076029620964868 – volume: 7 start-page: e630 issue: 9 year: 2020 ident: pone.0252939.ref034 article-title: Coagulation disorder in COVID-19. publication-title: The Lancet Haematology. doi: 10.1016/S2352-3026(20)30218-0 – volume: 100 start-page: 441 year: 2020 ident: pone.0252939.ref019 article-title: Meta-analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19 publication-title: International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases doi: 10.1016/j.ijid.2020.09.021 – year: 2020 ident: pone.0252939.ref020 article-title: Characteristics of coagulation alteration in patients with COVID-19 publication-title: Ann Hematol – volume: 7 start-page: 19 issue: 1 year: 2020 ident: pone.0252939.ref035 article-title: Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19. publication-title: Mil Med Res. – volume: 41 start-page: 185 issue: 3 year: 2020 ident: pone.0252939.ref031 article-title: Characteristics, causes, diagnosis and treatment of coagulation dysfunction in patients with COVID-19 publication-title: Zhonghua Xue Ye Xue Za Zhi – year: 2020 ident: pone.0252939.ref025 article-title: Anti-coagulation for COVID-19 treatment: both anti-thrombotic and anti-inflammatory? publication-title: J Thromb Thrombolysis – volume: 9 issue: 11 year: 2020 ident: pone.0252939.ref007 article-title: Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with COVID-19 publication-title: Journal of Clinical Medicine doi: 10.3390/jcm9113482 – volume: 194 start-page: 42 ident: pone.0252939.ref024 article-title: A comprehensive assessment of the coagulation profile in critically ill COVID-19 patients publication-title: Thromb Res doi: 10.1016/j.thromres.2020.06.026 – volume: 196 start-page: 209 year: 2020 ident: pone.0252939.ref029 article-title: Coagulation parameters and venous thromboembolism in patients with and without COVID-19 admitted to the Emergency Department for acute respiratory insufficiency publication-title: Thromb Res doi: 10.1016/j.thromres.2020.09.004 – volume: 136 start-page: 489 issue: 4 year: 2020 ident: pone.0252939.ref009 article-title: COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection publication-title: Blood doi: 10.1182/blood.2020006520 – volume: 2020 start-page: 1 ident: pone.0252939.ref005 article-title: Hemostatic Abnormalities in COVID-19: An Update. publication-title: Indian J Hematol Blood Transfus – volume: 508 start-page: 109 year: 2020 ident: pone.0252939.ref012 article-title: Thrombocytopenia and coagulation disorders due to COVID 19 infection with concomitant cardiovascular diseases requiring anti-platelet and anticoagulant therapy, which strategy? publication-title: Clin Chim Acta doi: 10.1016/j.cca.2020.05.031 – volume: 41 start-page: 100648 year: 2020 ident: pone.0252939.ref016 article-title: COVID-19 coagulopathy, thrombosis, and bleeding publication-title: Blood – year: 2020 ident: pone.0252939.ref018 article-title: Manifestations of blood coagulation and its relation to clinical outcomes in severe COVID-19 patients: Retrospective analysis publication-title: Int J Lab Hematol – volume: 4 start-page: 2850 issue: 12 ident: pone.0252939.ref013 article-title: COVID-19 coagulopathy vs disseminated intravascular coagulation publication-title: Blood Adv. 2020 doi: 10.1182/bloodadvances.2020002197 – year: 2020 ident: pone.0252939.ref008 article-title: COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment publication-title: Postgrad Med J – volume: 189 start-page: 1050 issue: 6 year: 2020 ident: pone.0252939.ref033 article-title: Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis publication-title: Br J Haematol doi: 10.1111/bjh.16725 – volume: 58 start-page: 1029 issue: 7 year: 2020 ident: pone.0252939.ref028 article-title: COVID-19: progression of disease and intravascular coagulation—present status and future perspectives publication-title: Clin Chem Lab Med doi: 10.1515/cclm-2020-0502 – volume: 9 start-page: 16 year: 2020 ident: pone.0252939.ref032 article-title: SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients publication-title: Exp Hematol Oncol. doi: 10.1186/s40164-020-00172-4 – volume: 2020 start-page: 6159720 year: 2020 ident: pone.0252939.ref003 article-title: D-Dimer and Prothrombin Time Are the Significant Indicators of Severe COVID-19 and Poor Prognosis publication-title: BioMed research international doi: 10.1155/2020/6159720 – volume: 50 start-page: 281 issue: 2 year: 2020 ident: pone.0252939.ref037 article-title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia publication-title: J Thromb Thrombolysis. doi: 10.1007/s11239-020-02130-7
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Snippet	Background Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in... Coagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in COVID-19... BackgroundCoagulopathy and thromboembolic events are among the complications of Corona Virus disease 2019 (COVID-19). Abnormal coagulation parameters in... About the Authors: Shambel Araya Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project...
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SubjectTerms	Abnormalities Biology and Life Sciences Biotechnology Blood Blood clotting Blood coagulation Coagulation Computer programs Corona Coronaviruses COVID-19 Data analysis Drafting software Editing Ethics Funding Health sciences Health services Infections Medical laboratories Medical prognosis Medical research Medical schools Medicine and Health Sciences Methodology Parameters Patients People and Places Polymerase chain reaction R&D Research & development Research ethics Respiratory distress syndrome Risk factors Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sociodemographics Software Statistical analysis Supervision Values Viral diseases Viruses Visualization
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Title	Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia
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