Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University

Introduction. To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin. Methods. This study is a matched case-control analysis concerning the type 2 diabetes population from Grenoble Hospital University. Cases...

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Bibliographic Details
Published in:Journal of Diabetes Research Vol. 2016; no. 2016; pp. 1 - 8
Main Authors: Chanoine, Sébastien, Yahiaoui, Nassima, Giai, Joris, Lepelley, Marion, Villier, Céline
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016
John Wiley & Sons, Inc
Hindawi Publishing Coporation
Wiley
Subjects:
Acidosis
Acidosis, Lactic - blood
Acidosis, Lactic - chemically induced
Acidosis, Lactic - diagnosis
Acidosis, Lactic - epidemiology
Acute Kidney Injury - epidemiology
Aged
Aged, 80 and over
Analysis
Anemia
Antidiabetics
Biomarkers - blood
Case-Control Studies
Chronic illnesses
Contraindications
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
Female
France - epidemiology
Heart failure
Hospitals
Hospitals, University
Humans
Hypoglycemic Agents - adverse effects
Insulin
Lactic Acid - blood
Lactic acidosis
Life Sciences
Male
Medication
Metformin
Metformin - adverse effects
Middle Aged
Mortality
Nonsteroidal anti-inflammatory drugs
Patients
Pharmaceutical sciences
Population
Risk Assessment
Risk Factors
Santé publique et épidémiologie
Studies
Treatment Outcome
ISSN:2314-6745, 2314-6753, 2314-6753
Online Access:Get full text
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Summary:Introduction. To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin. Methods. This study is a matched case-control analysis concerning the type 2 diabetes population from Grenoble Hospital University. Cases of LA were defined biologically with pH < 7.35 and lactates > 5 mmol/L. They were matched to 2 controls defined as type 2 diabetic inpatients who did not present a LA during the study period. We performed a conditional logistic regression. Results. We included 302 cases and 604 controls; mean age was 69.5 years (SD 11.93). Intercurrent diseases were significantly associated with LA. Chronic medical conditions had a minor impact on LA incidence, except hepatocellular dysfunction. Metformin was significantly associated with a higher LA probability in case of acute kidney injury (AKI) (OR = 1.79; p value = 0.020) but not in patients without AKI. Discussion and Conclusions. According to this study, metformin, compared to acute medical conditions, seemed not to be associated with LA in patients with type 2 diabetes; however in case of AKI, metformin may be associated with LA.
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PMCID: PMC4789438
Academic Editor: Mitsuhiko Noda
ISSN:2314-6745
2314-6753
2314-6753
DOI:10.1155/2016/3545914