Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University

Introduction. To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin. Methods. This study is a matched case-control analysis concerning the type 2 diabetes population from Grenoble Hospital University. Cases...

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Vydáno v:	Journal of Diabetes Research Ročník 2016; číslo 2016; s. 1 - 8
Hlavní autoři:	Chanoine, Sébastien, Yahiaoui, Nassima, Giai, Joris, Lepelley, Marion, Villier, Céline
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cairo, Egypt Hindawi Publishing Corporation 01.01.2016 John Wiley & Sons, Inc Hindawi Publishing Coporation Wiley
Témata:	Acidosis Acidosis, Lactic - blood Acidosis, Lactic - chemically induced Acidosis, Lactic - diagnosis Acidosis, Lactic - epidemiology Acute Kidney Injury - epidemiology Aged Aged, 80 and over Analysis Anemia Antidiabetics Biomarkers - blood Case-Control Studies Chronic illnesses Contraindications Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - epidemiology Female France - epidemiology Heart failure Hospitals Hospitals, University Humans Hypoglycemic Agents - adverse effects Insulin Lactic Acid - blood Lactic acidosis Life Sciences Male Medication Metformin Metformin - adverse effects Middle Aged Mortality Nonsteroidal anti-inflammatory drugs Patients Pharmaceutical sciences Population Risk Assessment Risk Factors Santé publique et épidémiologie Studies Treatment Outcome
ISSN:	2314-6745, 2314-6753, 2314-6753
On-line přístup:	Získat plný text
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Shrnutí:	Introduction. To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin. Methods. This study is a matched case-control analysis concerning the type 2 diabetes population from Grenoble Hospital University. Cases of LA were defined biologically with pH < 7.35 and lactates > 5 mmol/L. They were matched to 2 controls defined as type 2 diabetic inpatients who did not present a LA during the study period. We performed a conditional logistic regression. Results. We included 302 cases and 604 controls; mean age was 69.5 years (SD 11.93). Intercurrent diseases were significantly associated with LA. Chronic medical conditions had a minor impact on LA incidence, except hepatocellular dysfunction. Metformin was significantly associated with a higher LA probability in case of acute kidney injury (AKI) (OR = 1.79; p value = 0.020) but not in patients without AKI. Discussion and Conclusions. According to this study, metformin, compared to acute medical conditions, seemed not to be associated with LA in patients with type 2 diabetes; however in case of AKI, metformin may be associated with LA.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC4789438 Academic Editor: Mitsuhiko Noda
ISSN:	2314-6745 2314-6753 2314-6753
DOI:	10.1155/2016/3545914