Adverse outcomes after surgeries in patients with liver cirrhosis among Korean population: A population-based study

We used the Health Insurance Review and Assessment Service-National Inpatient Samples (HIRA-NIS) between 2012 and 2016. In-hospital mortality and hospital stay were analyzed using the data. Mortality rates according to the surgical department were also analyzed. Of the 1,662,887 patients who underwe...

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Published in:PloS one Vol. 16; no. 6; p. e0253165
Main Authors: Jo, Hyun Ho, Min, Changwook, Kyoung, Dae-Sung, Park, Min-Ae, Kim, Sang Gyune, Kim, Young Seok, Chang, Young, Jeong, Soung Won, Jang, Jae Young, Lee, Sae Hwan, Kim, Hong Soo, Jun, Baek Gyu, Kim, Young Don, Cheon, Gab Jin, Yoo, Jeong-Ju
Format: Journal Article
Language:English
Published: San Francisco Public Library of Science 14.06.2021
Public Library of Science (PLoS)
Subjects:
Adverse events
Antiviral agents
Antiviral drugs
Biology and Life Sciences
Chronic obstructive pulmonary disease
Cirrhosis
Codes
Complications and side effects
Disease
Fatty liver
Gastroenterology
Health insurance
Health risks
Hepatology
Hospitals
Internal medicine
Life expectancy
Life span
Liver
Liver cirrhosis
Liver diseases
Medicine
Medicine and Health Sciences
Mortality
Patient outcomes
Patients
Population
Population studies
Population-based studies
Prognosis
Regression analysis
Risk analysis
Risk factors
Surgery
Variables
South Korea
ISSN:1932-6203, 1932-6203
Online Access:Get full text
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Summary:We used the Health Insurance Review and Assessment Service-National Inpatient Samples (HIRA-NIS) between 2012 and 2016. In-hospital mortality and hospital stay were analyzed using the data. Mortality rates according to the surgical department were also analyzed. Of the 1,662,887 patients who underwent surgery, 16,174 (1.0%) patients had cirrhosis. The in-hospital mortality (8.0% vs. 1.0%) and postoperative complications such as respiratory (6.0% vs. 5.3%) or infections (2.8% vs. 2.4%) was significantly higher in patients with cirrhosis than in those without cirrhosis. In addition, the total hospitalization period and use of the intensive care unit were significantly higher in patients with liver cirrhosis. In propensity score matching analysis, liver cirrhosis increased the risk of adverse outcome significantly [adjusted OR (aOR) 1.67, 95% CI 1.56-1.79, P<0.001], especially in-hospital mortality. In liver cirrhosis group, presence of decompensation or varices showed significantly increased postoperative complication or mortality. Adverse outcomes in patients with cirrhosis was the highest in patients who underwent otorhinolaryngology surgery (aOR 1.86), followed by neurosurgery (aOR 1.72), thoracic and cardiovascular surgery (aOR 1.56), and plastic surgery (aOR 1.36). The adverse outcomes of patients with cirrhosis is significantly high after surgery, despite advances in cirrhosis treatment.
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Competing Interests: The authors have read the journal’s policy and have the following competing interests: DSK and MAP are paid employees of Hanmi Pharm. Co. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products associated with this research to declare.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0253165