Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over from 22 cohorts we identify 15 loci associated with muscle weakness (European Working...

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Vydané v:	Nature communications Ročník 12; číslo 1; s. 654 - 11
Hlavní autori:	Jones, Garan, Trajanoska, Katerina, Santanasto, Adam J., Stringa, Najada, Kuo, Chia-Ling, Atkins, Janice L., Lewis, Joshua R., Duong, ThuyVy, Hong, Shengjun, Biggs, Mary L., Luan, Jian’an, Sarnowski, Chloe, Lunetta, Kathryn L., Tanaka, Toshiko, Wojczynski, Mary K., Cvejkus, Ryan, Nethander, Maria, Ghasemi, Sahar, Yang, Jingyun, Zillikens, M. Carola, Walter, Stefan, Sicinski, Kamil, Kague, Erika, Ackert-Bicknell, Cheryl L., Arking, Dan E., Windham, B. Gwen, Boerwinkle, Eric, Grove, Megan L., Graff, Misa, Spira, Dominik, Demuth, Ilja, van der Velde, Nathalie, de Groot, Lisette C. P. G. M., Psaty, Bruce M., Odden, Michelle C., Fohner, Alison E., Langenberg, Claudia, Wareham, Nicholas J., Bandinelli, Stefania, van Schoor, Natasja M., Huisman, Martijn, Tan, Qihua, Zmuda, Joseph, Mellström, Dan, Karlsson, Magnus, Bennett, David A., Buchman, Aron S., De Jager, Philip L., Uitterlinden, Andre G., Völker, Uwe, Kocher, Thomas, Teumer, Alexander, Rodriguéz-Mañas, Leocadio, García, Francisco J., Carnicero, José A., Herd, Pamela, Bertram, Lars, Ohlsson, Claes, Murabito, Joanne M., Melzer, David, Kuchel, George A., Ferrucci, Luigi, Karasik, David, Rivadeneira, Fernando, Kiel, Douglas P., Pilling, Luke C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 28.01.2021 Nature Publishing Group Nature Portfolio
Predmet:	45 45/43 631/208/205 631/208/212 692/308/2056 692/53/2423 Aged Aged, 80 and over Aging Aging - genetics Arthritis Autoimmune diseases Basic Medicine Cell cycle Clinical Medicine Cohort Studies Diabetes mellitus Europe Female Gene regulation Genetic Predisposition to Disease - genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Geriatrics Geriatrik Grip strength Growth Differentiation Factor 5 - genetics Histocompatibility antigen HLA HLA-DQ alpha-Chains - genetics Humanities and Social Sciences Humans Immune system Klinisk medicin Loci Male Medical and Health Sciences Medical Genetics and Genomics Medical Genetics and Genomics (including Gene Therapy) Medicin och hälsovetenskap Medicinsk genetik och genomik Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Men Meta-analysis Middle Aged Morbidity Mortality multidisciplinary Muscle strength Muscle Strength - genetics Muscle Strength - physiology Muscle Weakness - genetics Muscle Weakness - physiopathology Musculoskeletal system Older people Polymorphism, Single Nucleotide Randomization Sarcopenia Sarcopenia - genetics Sarcopenia - physiopathology Science Science & Technology - Other Topics Science (multidisciplinary) Transcription Europe
ISSN:	2041-1723, 2041-1723
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