Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing the three-...

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Bibliographic Details
Published in:	BMC cancer Vol. 18; no. 1; pp. 869 - 11
Main Authors:	Ho, Vincent, Chung, Liping, Singh, Amandeep, Lea, Vivienne, Abubakar, Askar, Lim, Stephanie H., Ng, Weng, Lee, Mark, de Souza, Paul, Shin, Joo-Shik, Lee, Cheok Soon
Format:	Journal Article
Language:	English
Published:	London BioMed Central 03.09.2018 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Acid Anhydride Hydrolases Adult Aged Aged, 80 and over Analysis Biomarkers Biomedical and Life Sciences Biomedicine Bladder cancer Cancer Cancer patients Cancer recurrence Cancer Research Cancer therapies Care and treatment Cell and molecular biology Cell cycle Cell Cycle Proteins - genetics Chemoradiotherapy Colorectal cancer Confidence intervals Deoxyribonucleic acid Diagnosis Disease-Free Survival DNA DNA Breaks, Double-Stranded - radiation effects DNA damage DNA damage response DNA Repair Enzymes - genetics DNA-Binding Proteins - genetics Female Gene Expression Regulation, Neoplastic - radiation effects Genes Health aspects Health Promotion and Disease Prevention Health risk assessment Humans Immunohistochemistry Kaplan-Meier Estimate Kinases Lymphatic system Male Medical prognosis Medicine/Public Health Middle Aged Mortality MRE11 Homologue Protein - genetics MRE11 protein MRE11-RAD50-NBS1 complex Multiprotein Complexes - genetics Multivariate analysis Mutation Neoadjuvant radiotherapy Neoadjuvant therapy Neoadjuvant Therapy - adverse effects Nuclear Proteins - genetics Oncology Patients Prevention Prognosis Proteins Radiation therapy Radiosensitivity Rectal cancer Rectal Neoplasms - genetics Rectal Neoplasms - pathology Rectal Neoplasms - radiotherapy Rectum Research Article Surgery Surgical Oncology Survival Tissue Array Analysis Treatment outcome United States MRE11-RAD50-NBS1 complex Biomarkers Prognosis Neoadjuvant radiotherapy Rectal cancer DNA damage response
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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