Melatonin plays critical role in mesenchymal stem cell-based regenerative medicine in vitro and in vivo

Although stem cells have emerged as promising sources for regenerative medicine, there are many potential safety hazards for their clinical application, including tumorigenicity, an availability shortage, senescence, and sensitivity to toxic environments. Mesenchymal stem cells (MSCs) have various a...

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Vydáno v:Stem cell research & therapy Ročník 10; číslo 1; s. 13 - 11
Hlavní autoři: Hu, Chenxia, Li, Lanjuan
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 11.01.2019
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Apoptosis
Biomaterials
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedical materials
Bone marrow
Cell Biology
Cell Proliferation - genetics
Cytokines
Embryo cells
Embryonic Stem Cells - metabolism
Gene expression
Humans
In vitro
In vivo
Induced Pluripotent Stem Cells - metabolism
Ischemia
Life Sciences
Medicine
Melatonin
Melatonin - metabolism
Mesenchymal stem cell
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells - metabolism
Mesenchyme
Oxidation
Oxidative stress
Physiology
Pineal gland
Pluripotency
Protection
Reactive oxygen species
Regenerative Medicine
Regenerative Medicine/Tissue Engineering
Review
Senescence
Sepsis
Stem Cells
Transplantation
Tumorigenicity
Mesenchymal stem cell
In vivo
Therapy
Melatonin
Regenerative medicine
In vitro
Protection
ISSN:1757-6512, 1757-6512
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Shrnutí:Although stem cells have emerged as promising sources for regenerative medicine, there are many potential safety hazards for their clinical application, including tumorigenicity, an availability shortage, senescence, and sensitivity to toxic environments. Mesenchymal stem cells (MSCs) have various advantages compared to other stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); thus, MSCs have been intensely investigated in recent studies. However, they are placed in a harsh environment after isolation and transplantation, and the adverse microenvironment substantially reduces the viability and therapeutic effects of MSCs. Intriguingly, melatonin (MT), which is primarily secreted by the pineal organ, has been found to influence the fate of MSCs during various physiological and pathological processes. In this review, we will focus on the recent progress made regarding the influence of MT on stem cell biology and its implications for regenerative medicine. In addition, several biomaterials have been proven to significantly improve the protective effects of MT on MSCs by controlling the release of MT. Collectively, MT will be a promising agent for enhancing MSC activities and the regenerative capacity via the regulation of reactive oxygen species (ROS) generation and the release of immune factors in regenerative medicine.
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ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-018-1114-8