Inferring processes underlying B-cell repertoire diversity

We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the statistical properties of the naive repertoire, first after its in...

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Bibliographic Details
Published in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 370; no. 1676
Main Authors:	Elhanati, Yuval, Sethna, Zachary, Marcou, Quentin, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M
Format:	Journal Article
Language:	English
Published:	England 05.09.2015
Subjects:	Algorithms Antibody Diversity B-Lymphocytes - immunology Clonal Selection, Antigen-Mediated Humans Models, Genetic Models, Immunological Receptors, Antigen, B-Cell - genetics Somatic Hypermutation, Immunoglobulin V(D)J Recombination B cell immune repertoire somatic hypermutations statistical inference IgH VDJ recombination
ISSN:	1471-2970
Online Access:	Get more information
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