Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years

Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. We aimed to study associations between prenatal exposure to phthalates and several...

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Bibliographic Details
Published in:Environmental health perspectives Vol. 125; no. 9; pp. 097014 - 194027
Main Authors: Philippat, Claire, Nakiwala, Dorothy, Calafat, Antonia M., Botton, Jérémie, De Agostini, Maria, Heude, Barbara, Slama, Rémy
Format: Journal Article
Language:English
Published: United States National Institute of Environmental Health Sciences 01.09.2017
Environmental Health Perspectives
Subjects:
Autism
Behavior
Benzophenone
Biomarkers
Bisphenol A
Boys
Child
Child Behavior - drug effects
Children
Children & youth
Chromatography
Confidence intervals
Cosmetics
Creatinine
Emotional behavior
Emotions
Endocrine disruptors
Endocrine Disruptors - toxicity
Endocrine Disruptors - urine
Environmental Pollutants - toxicity
Environmental Pollutants - urine
Epidemiology
Exposure
Female
Food packaging
Health aspects
Health Impact Assessment
Humans
Hyperactivity
Infants
Male
Mental disorders
Metabolites
n-Butyl phthalate
Nervous system
Neurodevelopmental disorders
PCB
Personal grooming
Phenols
Phenols (Class of compounds)
Phthalates
Phthalic Acids - toxicity
Phthalic Acids - urine
Polychlorinated biphenyls
Population studies
Postpartum period
Pregnancy
Prenatal experience
Prenatal exposure
Prenatal Exposure Delayed Effects - epidemiology
Prenatal Exposure Delayed Effects - urine
Psychological aspects
Public health
Questionnaires
Response functions
Risk factors
Studies
Thyroid gland
Triclosan
Urine
Womens health
ISSN:0091-6765, 1552-9924, 1552-9924
Online Access:Get full text
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Summary:Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants. We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy. Mothers completed the Strength and Difficulties Questionnaire (SDQ) when their children were 3.1 (n=529) and 5.6 (n=464) y old. BPA was positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.11; 95% confidence interval (CI): 1.03, 1.20] and the hyperactivity-inattention subscale scores at 5 y (IRR: 1.08; 95% CI: 1.01, 1.14). Mono- -butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotional symptom scores at 3 y. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 y. After dichotomizing SDQ scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 y. The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose-response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314.
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ISSN:0091-6765
1552-9924
1552-9924
DOI:10.1289/EHP1314