Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We present a set of integrated experiments that investigate the effects of common genetic variability on DNA methylation and mRNA expr...

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Veröffentlicht in:	PLoS genetics Jg. 6; H. 5; S. e1000952
Hauptverfasser:	Gibbs, J. Raphael, van der Brug, Marcel P., Hernandez, Dena G., Traynor, Bryan J., Nalls, Michael A., Lai, Shiao-Lin, Arepalli, Sampath, Dillman, Allissa, Rafferty, Ian P., Troncoso, Juan, Johnson, Robert, Zielke, H. Ronald, Ferrucci, Luigi, Longo, Dan L., Cookson, Mark R., Singleton, Andrew B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 13.05.2010 Public Library of Science (PLoS)
Schlagworte:	Brain - metabolism Brain research Colleges & universities CpG Islands Deoxyribonucleic acid DNA DNA Methylation Epigenetics Experiments Gene Expression Genetics Genetics and Genomics/Bioinformatics Genetics and Genomics/Epigenetics Genetics and Genomics/Gene Expression Genomes Genomics Genotype Humans Polymorphism, Single Nucleotide Quantitative Trait Loci RNA, Messenger - genetics
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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