Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

Cytotoxic cancer therapy can induce accelerated growth of surviving cancer cells, a phenomenon known as tumor repopulation. This report uncovers a mechanism by which caspase 3 activation in treated cells promotes growth of surviving cells, mediated by iPLA 2 and PGE 2 . The level of caspase 3 activa...

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Bibliographic Details
Published in:	Nature medicine Vol. 17; no. 7; pp. 860 - 866
Main Authors:	Huang, Qian, Li, Fang, Liu, Xinjian, Li, Wenrong, Shi, Wei, Liu, Fei-Fei, O'Sullivan, Brian, He, Zhimin, Peng, Yuanlin, Tan, Aik-Choon, Zhou, Ling, Shen, Jingping, Han, Gangwen, Wang, Xiao-Jing, Thorburn, Jackie, Thorburn, Andrew, Jimeno, Antonio, Raben, David, Bedford, Joel S, Li, Chuan-Yuan
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.07.2011 Nature Publishing Group
Subjects:	631/67/1059/485 631/80/82/23 631/80/86 692/699/67 Animals Apoptosis Apoptosis - radiation effects Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Caspase 3 - metabolism Caspase 3 - physiology Cell Death - physiology Cell Death - radiation effects Cell Line, Tumor Cell Proliferation Cytotoxicity Dinoprostone - metabolism Dinoprostone - physiology Group VI Phospholipases A2 - metabolism Health aspects Humans Infectious Diseases Metabolic Diseases Mice Molecular Medicine Mortality Neoplasms, Experimental - radiotherapy Neurosciences Physiological aspects Prostaglandins E Radiation therapy Radiotherapy Repopulation Tumors United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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