Structural basis of RNA-dependent recruitment of glutamine to the genetic code

Glutaminyl-transfer RNA (Gln-tRNA(Gln)) in archaea is synthesized in a pretranslational amidation of misacylated Glu-tRNA(Gln) by the heterodimeric Glu-tRNA(Gln) amidotransferase GatDE. Here we report the crystal structure of the Methanothermobacter thermautotrophicus GatDE complexed to tRNA(Gln) at...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 312; H. 5782; S. 1950
Hauptverfasser:	Oshikane, Hiroyuki, Sheppard, Kelly, Fukai, Shuya, Nakamura, Yuko, Ishitani, Ryuichiro, Numata, Tomoyuki, Sherrer, R Lynn, Feng, Liang, Schmitt, Emmanuelle, Panvert, Michel, Blanquet, Sylvain, Mechulam, Yves, Söll, Dieter, Nureki, Osamu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 30.06.2006
Schlagworte:	Acylation Adenosine Triphosphate - metabolism Ammonia - metabolism Anticodon Binding Sites Catalytic Domain Computer Simulation Crystallography, X-Ray Dimerization Genetic Code Glutamine - metabolism Hydrogen Bonding Magnesium - metabolism Methanobacteriaceae - enzymology Methanobacteriaceae - genetics Models, Molecular Mutation Nitrogenous Group Transferases - chemistry Nitrogenous Group Transferases - metabolism Nucleic Acid Conformation Protein Structure, Quaternary Protein Structure, Secondary Protein Structure, Tertiary RNA, Archaeal - chemistry RNA, Archaeal - metabolism RNA, Transfer, Gln - chemistry RNA, Transfer, Gln - metabolism
ISSN:	1095-9203, 1095-9203
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