The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

Suzanne Baker, Jinghui Zhang and colleagues report the identification of recurrent somatic mutations in the bone morphogenetic protein (BMP) receptor ACVR1 in 32% of diffuse intrinsic pontine gliomas. Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 yea...

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Bibliographic Details
Published in:	Nature genetics Vol. 46; no. 5; pp. 444 - 450
Main Authors:	Wu, Gang, Diaz, Alexander K, Paugh, Barbara S, Rankin, Sherri L, Ju, Bensheng, Li, Yongjin, Zhu, Xiaoyan, Qu, Chunxu, Chen, Xiang, Zhang, Junyuan, Easton, John, Edmonson, Michael, Ma, Xiaotu, Lu, Charles, Nagahawatte, Panduka, Hedlund, Erin, Rusch, Michael, Pounds, Stanley, Lin, Tong, Onar-Thomas, Arzu, Huether, Robert, Kriwacki, Richard, Parker, Matthew, Gupta, Pankaj, Becksfort, Jared, Wei, Lei, Mulder, Heather L, Boggs, Kristy, Vadodaria, Bhavin, Yergeau, Donald, Russell, Jake C, Ochoa, Kerri, Fulton, Robert S, Fulton, Lucinda L, Jones, Chris, Boop, Frederick A, Broniscer, Alberto, Wetmore, Cynthia, Gajjar, Amar, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Taylor, Michael R, Downing, James R, Ellison, David W, Zhang, Jinghui, Baker, Suzanne J
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.05.2014 Nature Publishing Group
Subjects:	45 45/23 45/91 631/208/514/1948 64 64/116 64/60 692/699/67/1922 Activin Receptors, Type I - genetics Age Agriculture Animal Genetics and Genomics Animals Bioinformatics Biomedicine Brain Stem Neoplasms - genetics Cancer Cancer Research Child Children & youth Cohort Studies Computational Biology Gene Expression Profiling Gene Function Gene Fusion - genetics Genes Genetic aspects Genetic research Genomes Genomics Glioma - genetics Gliomas Human Genetics Humans Immunoblotting Immunohistochemistry Kinases letter Medical prognosis Microarray Analysis Mutation Pediatrics Receptor, trkA - genetics Receptor, trkB - genetics Receptor, trkC - genetics Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Signal Transduction - genetics Statistics, Nonparametric Survival Tumors Tumors in children Zebrafish
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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