Hidden Markov model speed heuristic and iterative HMM search procedure

Background Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require considerable time to search large sequence databases. Results We have designed a series of database filtering steps, HMMERHEA...

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Vydané v:	BMC bioinformatics Ročník 11; číslo 1; s. 431
Hlavní autori:	Johnson, L Steven, Eddy, Sean R, Portugaly, Elon
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 18.08.2010 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Algorithms Artificial Intelligence Base Sequence Bioinformatics Biomedical and Life Sciences Comparative genomics Computational biology Computational Biology/Bioinformatics Computer Appl. in Life Sciences Computer science Databases, Protein Genetic algorithms Hidden Markov models Iterative methods Life Sciences Markov Chains Methods Microarrays Proteins Proteins - chemistry Research Article Sequence Alignment - methods Software Studies United States Test Database Search Time Profile Hide Markov Model Entropy Weighting Iterative Search
ISSN:	1471-2105, 1471-2105
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