Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation

Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. Not much is known about the formation of these vesicles, although recent observations indicate an important role for the endoplasmic reticulum in the formation of the mouse hepat...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 4; no. 6; p. e1000088
Main Authors:	Verheije, Monique H., Raaben, Matthijs, Mari, Muriel, te Lintelo, Eddie G., Reggiori, Fulvio, van Kuppeveld, Frank J. M., Rottier, Peter J. M., de Haan, Cornelis A. M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.06.2008 Public Library of Science (PLoS)
Subjects:	ADP-Ribosylation Factor 1 - genetics ADP-Ribosylation Factor 1 - metabolism Animals Brefeldin A - pharmacology Causes of Cell Line Coronavirus Coronavirus Infections - immunology Coronavirus Infections - virology Coronaviruses Dogs Guanine Nucleotide Exchange Factors - physiology Health aspects Hepatitis Humans Medical research Mice Microscopy Murine hepatitis virus - physiology Mutation Physiological aspects Proteins R&D Research & development RNA RNA, Small Interfering - pharmacology RNA, Viral - biosynthesis Virology/Viral and Gene Regulation Viruses Netherlands
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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