Rapid Molecular Detection of Rifampicin Resistance Facilitates Early Diagnosis and Treatment of Multi-Drug Resistant Tuberculosis: Case Control Study

Multi-drug resistant tuberculosis (MDR-TB) is a major public health concern since diagnosis is often delayed, increasing the risk of spread to the community and health care workers. Treatment is prolonged, and the total cost of treating a single case is high. Diagnosis has traditionally relied upon...

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Bibliographic Details
Published in:	PloS one Vol. 3; no. 9; p. e3173
Main Authors:	O'Riordan, Philly, Schwab, Uli, Logan, Sarah, Cooke, Graham, Wilkinson, Robert J., Davidson, Robert N., Bassett, Paul, Wall, Robert, Pasvol, Geoffrey, Flanagan, Katie L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 09.09.2008 Public Library of Science (PLoS)
Subjects:	Acid resistance Antibiotics, Antitubercular - pharmacology Bacilli Care and treatment Case-Control Studies Control Demographics Demography Diagnosis Diagnostic systems DNA-directed RNA polymerase Drug resistance Epidemiology Female Health care Health surveillance Hospitals Humans Impact analysis Infections Infectious Diseases/Antimicrobials and Drug Resistance Infectious Diseases/Bacterial Infections Laboratories Lung diseases Male Medical diagnosis Medical personnel Medical records Medical research Medicine Microbiology Microbiology/Medical Microbiology Multidrug resistance Multidrug resistant organisms Mutation Patients Public health Retrospective Studies Ribonucleic acid Rifampin Rifampin - pharmacology Risk Risk analysis Risk Factors RNA RNA polymerase RNA Polymerase II - genetics RpoB protein Sensitivity Studies Test procedures Therapy Thorax Treatment Outcome Tuberculosis Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - prevention & control Tuberculosis, Multidrug-Resistant - transmission Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - prevention & control Tuberculosis, Pulmonary - transmission United Kingdom > UK England South Africa
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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