Nuclear Phosphatidylcholine and Sphingomyelin Metabolism of Thyroid Cells Changes during Stratospheric Balloon Flight

Nuclear sphingomyelin and phosphatidylcholine metabolism is involved in the response to ultraviolet radiation treatment in different ways related to the physiological state of cells. To evaluate the effects of low levels of radiation from the stratosphere on thyroid cells, proliferating and quiescen...

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Vydané v:	BioMed research international Ročník 2009; číslo 2009; s. 1 - 5
Hlavní autori:	Perrella, Giuseppina, Villani, Maristella, Cataldi, Samuela, Albi, Elisabetta
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Cairo, Egypt Hindawi Puplishing Corporation 01.01.2009 Hindawi Publishing Corporation Dar al -Nasr -al-Llktruni John Wiley & Sons, Inc
Predmet:	Animals Apoptosis Apoptosis - radiation effects Biological and medical sciences Cell division Cell Nucleus - metabolism Cell Nucleus - radiation effects Cells, Cultured Colleges & universities Cosmic Radiation Free radicals Human subjects Lipid metabolism Lipids Medical sciences Mitochondrial DNA Pharmacology. Drug treatments Phosphatidylcholines - metabolism Physiological aspects Radiation Dosage Rats Signal Transduction - physiology Skin cancer Space Flight Sphingomyelins - metabolism Thyroid Gland - cytology Thyroid Gland - metabolism Thyroid Gland - radiation effects Ultraviolet radiation Ultraviolet Rays Italy Endocrine gland Sounding balloon Flight Phosphatidylcholine Sphingomyelin Thyroid gland Pharmacokinetics Metabolism In vitro
ISSN:	1110-7243, 2314-6133, 1110-7251, 1110-7251, 2314-6141
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Popis
Shrnutí:	Nuclear sphingomyelin and phosphatidylcholine metabolism is involved in the response to ultraviolet radiation treatment in different ways related to the physiological state of cells. To evaluate the effects of low levels of radiation from the stratosphere on thyroid cells, proliferating and quiescent FRTL-5 cells were flown in a stratospheric balloon (BIRBA mission). After recovery, the activity of neutral sphingomyelinase, phosphatidylcholine-specific phospholipase C, sphingomyelin synthase, and reverse sphingomyelin synthase was assayed in purified nuclei and the nuclei-free fraction. In proliferating FRTL-5, space radiation stimulate nuclear neutral sphingomyelinase and reverse sphingomyelin synthase activity, whereas phosphatidylcholine-specific phospholipase C and sphingomyelin synthase were inhibited, thus inducing sphingomyelin degradation and phosphatidylcholine synthesis. This effect was lower in quiescent cells. The possible role of nuclear lipid metabolism in the thyroid damage induced by space radiations is discussed.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Recommended by Yusuf Hannun
ISSN:	1110-7243 2314-6133 1110-7251 1110-7251 2314-6141
DOI:	10.1155/2009/125412