Nuclear Phosphatidylcholine and Sphingomyelin Metabolism of Thyroid Cells Changes during Stratospheric Balloon Flight

Nuclear sphingomyelin and phosphatidylcholine metabolism is involved in the response to ultraviolet radiation treatment in different ways related to the physiological state of cells. To evaluate the effects of low levels of radiation from the stratosphere on thyroid cells, proliferating and quiescen...

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Vydáno v:BioMed research international Ročník 2009; číslo 2009; s. 1 - 5
Hlavní autoři: Perrella, Giuseppina, Villani, Maristella, Cataldi, Samuela, Albi, Elisabetta
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2009
Hindawi Publishing Corporation
Dar al -Nasr -al-Llktruni
John Wiley & Sons, Inc
Témata:
Animals
Apoptosis
Apoptosis - radiation effects
Biological and medical sciences
Cell division
Cell Nucleus - metabolism
Cell Nucleus - radiation effects
Cells, Cultured
Colleges & universities
Cosmic Radiation
Free radicals
Human subjects
Lipid metabolism
Lipids
Medical sciences
Mitochondrial DNA
Pharmacology. Drug treatments
Phosphatidylcholines - metabolism
Physiological aspects
Radiation Dosage
Rats
Signal Transduction - physiology
Skin cancer
Space Flight
Sphingomyelins - metabolism
Thyroid Gland - cytology
Thyroid Gland - metabolism
Thyroid Gland - radiation effects
Ultraviolet radiation
Ultraviolet Rays
Italy
Endocrine gland
Sounding balloon
Flight
Phosphatidylcholine
Sphingomyelin
Thyroid gland
Pharmacokinetics
Metabolism
In vitro
ISSN:1110-7243, 2314-6133, 1110-7251, 1110-7251, 2314-6141
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Shrnutí:Nuclear sphingomyelin and phosphatidylcholine metabolism is involved in the response to ultraviolet radiation treatment in different ways related to the physiological state of cells. To evaluate the effects of low levels of radiation from the stratosphere on thyroid cells, proliferating and quiescent FRTL-5 cells were flown in a stratospheric balloon (BIRBA mission). After recovery, the activity of neutral sphingomyelinase, phosphatidylcholine-specific phospholipase C, sphingomyelin synthase, and reverse sphingomyelin synthase was assayed in purified nuclei and the nuclei-free fraction. In proliferating FRTL-5, space radiation stimulate nuclear neutral sphingomyelinase and reverse sphingomyelin synthase activity, whereas phosphatidylcholine-specific phospholipase C and sphingomyelin synthase were inhibited, thus inducing sphingomyelin degradation and phosphatidylcholine synthesis. This effect was lower in quiescent cells. The possible role of nuclear lipid metabolism in the thyroid damage induced by space radiations is discussed.
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Recommended by Yusuf Hannun
ISSN:1110-7243
2314-6133
1110-7251
1110-7251
2314-6141
DOI:10.1155/2009/125412