Comprehensive analysis of iron utilization by Mycobacterium tuberculosis

Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis (Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes siderophores, small molecules with high affinity for iron, and takes up iron-loaded mycobactins (MBT) and carboxymycobacti...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 16; no. 2; p. e1008337
Main Authors:	Zhang, Lei, Hendrickson, R. Curtis, Meikle, Virginia, Lefkowitz, Elliot J., Ioerger, Thomas R., Niederweis, Michael
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 18.02.2020 Public Library of Science (PLoS)
Subjects:	Amide Synthases - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological Transport Biology and Life Sciences Chromosomes Efflux Genetic research Glycosylated hemoglobin Heme Heme - metabolism Hemoglobin Hemoglobins Hemoglobins - metabolism Humans Infections Iron Iron - metabolism Medicine and Health Sciences Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mutants Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Novels Oxazoles - metabolism Pathogenic microorganisms Physiological aspects Proteins Research and Analysis Methods Secretion Siderophores Siderophores - metabolism Software Transcription Transcription (Genetics) Transposon mutagenesis Transposons Tuberculosis Utilization Virulence Alabama United States > US Texas
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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