Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

Chronic activation of the immune system in HIV infection is one of the strongest predictors of morbidity and mortality. As such, approaches that reduce immune activation have received considerable interest. Previously, we demonstrated that administration of a type I interferon receptor antagonist (I...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 14; no. 8; p. e1007246
Main Authors:	Nganou-Makamdop, Krystelle, Billingsley, James M., Yaffe, Zachary, O’Connor, Gregory, Tharp, Gregory K., Ransier, Amy, Laboune, Farida, Matus-Nicodemos, Rodrigo, Lerner, Andrea, Gharu, Lavina, Robertson, Jennifer M., Ford, Mandy L., Schlapschy, Martin, Kuhn, Nadine, Lensch, Alexandra, Lifson, Jeffrey, Nason, Martha, Skerra, Arne, Schreiber, Gideon, Bosinger, Steven E., Douek, Daniel C.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.08.2018 Public Library of Science (PLoS)
Subjects:	Acquired immune deficiency syndrome AIDS Animals Anti-Retroviral Agents - pharmacology Anti-Retroviral Agents - therapeutic use Antiretroviral therapy Biology and Life Sciences CD223 antigen CD38 antigen CD4 antigen Cell activation Cellular signal transduction Chronic Disease Chronic infection Cytokines Deoxyribonucleic acid Development and progression DNA Exhaustion Gag protein Gene expression Gene sequencing Genetic aspects Histocompatibility antigen HLA HIV Human immunodeficiency virus Immune system Inflammation Inflammation - immunology Inflammation - prevention & control Inflammation - virology Interferon Interferon Type I - antagonists & inhibitors Interferon Type I - metabolism Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 6 Interleukin 8 Lymph nodes Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Macaca mulatta Medicine and Health Sciences Morbidity PD-1 protein Peripheral blood Plasma levels Receptors, Interferon - antagonists & inhibitors Replication Research and Analysis Methods Retrovirus infections Ribonucleic acid Risk factors RNA RNA sequencing Signal transduction Signal Transduction - drug effects Signal Transduction - immunology Signaling Simian Acquired Immunodeficiency Syndrome - drug therapy Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - drug effects Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - physiology T-Lymphocytes - drug effects T-Lymphocytes - immunology Viral infections Virus replication Virus Replication - drug effects Viruses Atlanta Georgia Georgia United States > US Maryland Germany
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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