Autophagy regulates UBC9 levels during viral-mediated tumorigenesis

UBC9, the sole E2-conjugating enzyme required for SUMOylation, is a key regulator of essential cellular functions and, as such, is frequently altered in cancers. Along these lines, we recently reported that its expression gradually increases during early stages of human papillomavirus (HPV)-mediated...

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Veröffentlicht in:	PLoS pathogens Jg. 13; H. 3; S. e1006262
Hauptverfasser:	Mattoscio, Domenico, Casadio, Chiara, Miccolo, Claudia, Maffini, Fausto, Raimondi, Andrea, Tacchetti, Carlo, Gheit, Tarik, Tagliabue, Marta, Galimberti, Viviana E., De Lorenzi, Francesca, Pawlita, Michael, Chiesa, Fausto, Ansarin, Mohssen, Tommasino, Massimo, Chiocca, Susanna
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.03.2017 Public Library of Science (PLoS)
Schlagworte:	Apoptosis Autophagy Autophagy (Cytology) Autophagy - physiology Biology and life sciences Brain cancer Carcinogens Care and treatment Cell cycle Cell death Cell Transformation, Neoplastic Cell Transformation, Viral - physiology Cellular proteins Cervical cancer Development and progression Enzymes Female Flow Cytometry Genetic aspects Genetic transformation Head Head & neck cancer Head and neck Health aspects Human papillomavirus Humans Immunoblotting Immunohistochemistry Infections Keratinocytes Lesions Medical research Medicine and Health Sciences Microscopy, Confocal Oncogene Proteins, Viral Oncology Otolaryngology p53 Protein Papillomaviridae - metabolism Papillomavirus infections Papillomavirus Infections - metabolism Papillomavirus Infections - pathology Pathology Phagocytosis Pharmacology Polymerase Chain Reaction Proteins Research and Analysis Methods Rodents SUMO protein Surgery Tissues Transduction, Genetic Transfection Transformation Tumorigenesis Ubiquitin-Conjugating Enzyme UBC9 Ubiquitin-Conjugating Enzymes - metabolism Viruses
ISSN:	1553-7374, 1553-7366, 1553-7374
Online-Zugang:	Volltext
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