The Wnt signaling pathway in cancer

The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the beha...

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Veröffentlicht in:Critical reviews in oncology/hematology Jg. 99; S. 141 - 149
Hauptverfasser: Duchartre, Yann, Kim, Yong-Mi, Kahn, Michael
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ireland Ltd 01.03.2016
Schlagworte:
Animals
Antineoplastic Agents - therapeutic use
Cancer Stem Cells
Hematology, Oncology and Palliative Medicine
Humans
Microenvironment
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - metabolism
Wnt Signaling Pathway - drug effects
Wnt-signaling
Wnt-signaling
Microenvironment
Cancer Stem Cells
ISSN:1040-8428, 1879-0461
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Zusammenfassung:The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs). CSCs are considered by most to be responsible for establishment of the tumor and also for disease relapse, as they possess inherent drug-resistance properties. The development of new therapeutic compounds targeting the Wnt signaling pathway promises new hope to eliminate CSCs and achieve cancer eradication. However, a major challenge resides in developing a strategy efficient enough to target the dysregulated Wnt pathway in CSCs, while being safe enough to not damage the normal somatic stem cell population required for tissue homeostasis and repair. Here we review recent therapeutic approaches to target the Wnt pathway and their clinical applications.
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ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.12.005