Up-down biphasic volume response of human red blood cells to PIEZO1 activation during capillary transits

In this paper we apply a novel JAVA version of a model on the homeostasis of human red blood cells (RBCs) to investigate the changes RBCs experience during single capillary transits. In the companion paper we apply a model extension to investigate the changes in RBC homeostasis over the approximatel...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 17; no. 3; p. e1008706
Main Authors:	Rogers, Simon, Lew, Virgilio L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 03.03.2021 Public Library of Science (PLoS)
Subjects:	Age Biology and Life Sciences Blood Blood cells Ca2+-transporting ATPase Calcium Calcium - metabolism Calcium ions Capillaries - physiology Carbon dioxide Cell activation Channel gating Computer applications Computer programs Deformation Energy costs Erythrocytes Erythrocytes - cytology Erythrocytes - metabolism Erythrocytes - physiology Health aspects Homeostasis Humans In vivo methods and tests Ion Channels - metabolism Java (programming language) Life span Medicine and Health Sciences Membranes Metabolism Models, Cardiovascular Permeability Physical Sciences Potassium channels (calcium-gated) Red blood cells Rheology Stress, Mechanical United Kingdom
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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