The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans

The cyclic GMP-AMP synthase (cGAS)-STING pathway is central for innate immune sensing of various bacterial, viral and protozoal infections. Recent studies identified the common HAQ and R232H alleles of TMEM173/STING, but the functional consequences of these variants for primary infections are unknow...

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Veröffentlicht in:	PLoS pathogens Jg. 14; H. 1; S. e1006829
Hauptverfasser:	Ruiz-Moreno, Juan S., Hamann, Lutz, Shah, Javeed A., Verbon, Annelies, Mockenhaupt, Frank P., Puzianowska-Kuznicka, Monika, Naujoks, Jan, Sander, Leif E., Witzenrath, Martin, Cambier, John C., Suttorp, Norbert, Schumann, Ralf R., Jin, Lei, Hawn, Thomas R., Opitz, Bastian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.01.2018 Public Library of Science (PLoS)
Schlagworte:	Adult Aged Aged, 80 and over AMP Analysis Animal diseases Animals Anti-Bacterial Agents - therapeutic use Antibacterial agents Antiinfectives and antibacterials Bacteria Biology and Life Sciences Case-Control Studies Cells, Cultured Clinical trials Cyclic GMP Cytokines Deoxyribonucleic acid Disease control Disease susceptibility DNA Female Gene expression Genetic Predisposition to Disease Haplotypes Health aspects HEK293 Cells Humans Immune response Immunity, Innate - drug effects Immunity, Innate - genetics Infection Infections Infectious diseases Inflammation Internal medicine Kinases Legionella Legionella pneumophila - immunology Legionnaire's disease Legionnaires' disease Legionnaires' Disease - drug therapy Legionnaires' Disease - genetics Legionnaires' disease bacterium Macrophages Male Medical research Medicine Medicine and Health Sciences Membrane Proteins - genetics Mice Mice, Inbred C57BL Middle Aged Nucleotidyltransferases - physiology Polymorphism, Genetic Research and Analysis Methods Treatment Outcome Tuberculosis Poland United States > US Germany
ISSN:	1553-7374, 1553-7366, 1553-7374
Online-Zugang:	Volltext
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