The C4 protein encoded by tomato leaf curl Yunnan virus reverses transcriptional gene silencing by interacting with NbDRM2 and impairing its DNA-binding ability

In plants, cytosine DNA methylation is an efficient defense mechanism against geminiviruses, since methylation of the viral genome results in transcriptional gene silencing (TGS). As a counter-defense mechanism, geminiviruses encode viral proteins to suppress viral DNA methylation and TGS. However,...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 16; no. 10; p. e1008829
Main Authors:	Mei, Yuzhen, Wang, Yaqin, Li, Fangfang, Zhou, Xueping
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.10.2020 Public Library of Science (PLoS)
Subjects:	Antiviral agents Antiviral drugs Begomovirus - physiology Binding Biology Biology and Life Sciences Biotechnology C4 protein Cytosine Deactivation Defense mechanisms Deoxyribonucleic acid DNA DNA Methylation DNA methyltransferase DNA, Viral - genetics DNA, Viral - metabolism DNA-ligand interactions Engineering and Technology Gene expression Gene Silencing Genetic aspects Genome, Viral Genomes Host-Pathogen Interactions - genetics Inactivation Kinases Laboratories Leaf-curl Leaves Methyltransferases Molecular modelling Mutants Nicotiana - genetics Nicotiana - metabolism Nicotiana - virology Observations Physical Sciences Plant diseases Plant Diseases - immunology Plant Diseases - virology Plant Proteins - genetics Plant Proteins - metabolism Plants, Genetically Modified - genetics Plants, Genetically Modified - metabolism Plants, Genetically Modified - virology Properties Proteins Research and Analysis Methods Rice Tomatoes Transcription, Genetic Viral infections Viral proteins Viral Proteins - genetics Viral Proteins - metabolism Viruses China Beijing China Yunnan China
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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