Complete blood counts with red blood cell determinants associate with reduced beta‐cell function in seroconverted Swedish TEDDY children
Objectives To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. Methods The Environmental Determinants of Diabetes in the Young...
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| Vydáno v: | Endocrinology, diabetes & metabolism Ročník 4; číslo 3; s. e00251 - n/a |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
John Wiley & Sons, Inc
01.07.2021
John Wiley and Sons Inc Wiley |
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| ISSN: | 2398-9238, 2398-9238 |
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| Abstract | Objectives
To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time.
Methods
The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c.
Results
HbA1c over time increased by the number of autoantibodies (p < .001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c (p < .001). A reduction in red blood cell (RBC) counts (p = .003), haemoglobin (p = .002) and haematocrit (p = .006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin.
Conclusions
The decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta‐cell autoimmunity.
Islet beta cell autoantibody positive children with increased risk for developing type 1 diabetes have reduced red blood cell counts and parameters associated with impaired glucose metabolism. |
|---|---|
| AbstractList | To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time.OBJECTIVESTo investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time.The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c.METHODSThe Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c.HbA1c over time increased by the number of autoantibodies (p < .001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c (p < .001). A reduction in red blood cell (RBC) counts (p = .003), haemoglobin (p = .002) and haematocrit (p = .006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin.RESULTSHbA1c over time increased by the number of autoantibodies (p < .001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c (p < .001). A reduction in red blood cell (RBC) counts (p = .003), haemoglobin (p = .002) and haematocrit (p = .006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin.The decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta-cell autoimmunity.CONCLUSIONSThe decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta-cell autoimmunity. Objectives To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. Methods The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c. Results HbA1c over time increased by the number of autoantibodies (p < .001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c (p < .001). A reduction in red blood cell (RBC) counts (p = .003), haemoglobin (p = .002) and haematocrit (p = .006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin. Conclusions The decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta‐cell autoimmunity. Islet beta cell autoantibody positive children with increased risk for developing type 1 diabetes have reduced red blood cell counts and parameters associated with impaired glucose metabolism. Abstract Objectives To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. Methods The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c. Results HbA1c over time increased by the number of autoantibodies (p < .001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c (p < .001). A reduction in red blood cell (RBC) counts (p = .003), haemoglobin (p = .002) and haematocrit (p = .006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin. Conclusions The decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta‐cell autoimmunity. Objectives: To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c. Results: HbA1c over time increased by the number of autoantibodies (p <.001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c (p <.001). A reduction in red blood cell (RBC) counts (p =.003), haemoglobin (p =.002) and haematocrit (p =.006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin. Conclusions: The decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta-cell autoimmunity. To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c. HbA1c over time increased by the number of autoantibodies ( < .001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c ( < .001). A reduction in red blood cell (RBC) counts ( = .003), haemoglobin ( = .002) and haematocrit ( = .006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin. The decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta-cell autoimmunity. Islet beta cell autoantibody positive children with increased risk for developing type 1 diabetes have reduced red blood cell counts and parameters associated with impaired glucose metabolism. ObjectivesTo investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time.MethodsThe Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c.ResultsHbA1c over time increased by the number of autoantibodies (p < .001). Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c (p < .001). A reduction in red blood cell (RBC) counts (p = .003), haemoglobin (p = .002) and haematocrit (p = .006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin.ConclusionsThe decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta‐cell autoimmunity. |
| Author | Salami, Falastin Lernmark, Åke Törn, Carina Elding Larsson, Helena N.Tamura, Roy |
| AuthorAffiliation | 1 Department of Clinical Sciences Clinical Research Centre Lund University Skåne University Hospital Malmö Sweden 2 Health Informatics Institute Department of Pediatrics University of South Florida Tampa Florida USA |
| AuthorAffiliation_xml | – name: 1 Department of Clinical Sciences Clinical Research Centre Lund University Skåne University Hospital Malmö Sweden – name: 2 Health Informatics Institute Department of Pediatrics University of South Florida Tampa Florida USA |
| Author_xml | – sequence: 1 givenname: Falastin orcidid: 0000-0002-0098-4287 surname: Salami fullname: Salami, Falastin email: falastin.salami@med.lu.se organization: Skåne University Hospital – sequence: 2 givenname: Roy surname: N.Tamura fullname: N.Tamura, Roy organization: University of South Florida – sequence: 3 givenname: Helena surname: Elding Larsson fullname: Elding Larsson, Helena organization: Skåne University Hospital – sequence: 4 givenname: Åke surname: Lernmark fullname: Lernmark, Åke organization: Skåne University Hospital – sequence: 5 givenname: Carina surname: Törn fullname: Törn, Carina organization: Skåne University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34277975$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00125_024_06247_9 crossref_primary_10_1186_s12902_023_01435_x crossref_primary_10_1111_pedi_13413 |
| Cites_doi | 10.1007/s11892-018-1113-2 10.4081/cp.2017.999 10.1373/clinchem.2016.257659 10.1373/clinchem.2010.148221 10.1016/S0140-6736(16)30582-7 10.2337/dc15-1419 10.1007/978-981-13-9589-5_2 10.1111/j.1365-2141.2006.06279.x 10.1210/jc.2010-0293 10.1210/jc.2018-00433 10.2337/db14-0497 10.1007/BF01506150 10.3390/ijerph110505497 10.2337/dc17-0238 10.1055/s-0032-1301901 10.1016/0003-2697(68)90361-8 10.2337/dc11-1321 10.1038/s41591-019-0667-0 10.1016/j.diabres.2016.07.027 10.1016/j.molmet.2019.06.010 10.1196/annals.1447.062 10.1053/jpan.2003.50013 10.1373/clinchem.2010.148841 10.1007/s00125-018-4561-y 10.2337/diacare.27.2.491 10.1002/9781119513469 10.1111/j.1751-553X.2007.00971.x 10.1210/jc.2019-00421 10.1007/s00125-015-3599-3 10.2337/db18-0355 10.1001/jama.2013.6285 10.1002/dmrr.2427 10.1016/S0140-6736(09)60568-7 10.1111/j.1399-5448.2007.00269.x 10.1111/pedi.12485 10.1056/NEJMc1706291 10.1111/j.1399-5448.2011.00774.x 10.1172/jci.insight.122146 10.1111/j.1464-5491.2007.02161.x 10.1016/j.cca.2011.12.019 10.2337/dc16-0181 10.1182/blood.V70.6.1959.1959 10.2337/db12-1345 |
| ContentType | Journal Article |
| Copyright | 2021 The Authors. published by John Wiley & Sons Ltd. 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| CorporateAuthor | the TEDDY Study Group TEDDY Study Group LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning Institutionen för kliniska vetenskaper, Lund Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Neurosurgery Lund University Celiac Disease and Diabetes Unit Department of Clinical Sciences, Lund Strategiska forskningsområden (SFO) Neurokirurgi EXODIAB: Excellence of Diabetes Research in Sweden Faculty of Medicine Celiaki och diabetes Strategic research areas (SRA) Section IV Medicinska fakulteten Sektion IV Profilområden och andra starka forskningsmiljöer Pediatrisk endokrinologi Institutionen för kliniska vetenskaper, Malmö LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research Paediatric Endocrinology |
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| Keywords | red blood cells type 1 diabetes autoimmunity HbA1c glucose metabolism |
| Language | English |
| License | Attribution 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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| Notes | The TEDDY study group is listed in the online supplemental appendix. funding information The current study is funded by U01 DK63829, U01 DK63861 (SWE), U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483 and Contract No. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Environmental Health Sciences (NIEHS), Centers for Disease Control and Prevention (CDC) and JDRF. This study was supported in part by the SUS Funds & Donations and the Swedish Foundation for Strategic Research Dnr IRC15‐0067 and Swedish Research Council, Strategic Research Area, Dnr 2009‐1039 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| PublicationDate | July 2021 |
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| PublicationTitle | Endocrinology, diabetes & metabolism |
| PublicationTitleAlternate | Endocrinol Diabetes Metab |
| PublicationYear | 2021 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
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| References_xml | – volume: 104 start-page: 4521 issue: 10 year: 2019 end-page: 4530 article-title: Age at seroconversion, HLA genotype, and specificity of autoantibodies in progression of islet autoimmunity in childhood publication-title: J Clin Endocrinol Metabol – volume: 57 start-page: 176 issue: 2 year: 2011 end-page: 185 article-title: Genetics of type 1 diabetes publication-title: Clin Chem – volume: 30 start-page: 400 issue: 5 year: 2008 end-page: 407 article-title: Performance evaluation of Abbott CELL‐DYN Ruby for routine use publication-title: Int J Lab Hematol – volume: 58 start-page: 1409 issue: 7 year: 2015 end-page: 1421 article-title: The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review publication-title: Diabetologia – volume: 27 start-page: 491 issue: 2 year: 2004 end-page: 496 article-title: Elevated white blood cell count in subjects with impaired glucose tolerance publication-title: Diabetes Care – volume: 67 start-page: 2329 issue: 11 year: 2018 end-page: 2336 article-title: Reduction in white blood cell, neutrophil, and red blood cell counts related to sex, HLA, and islet autoantibodies in Swedish TEDDY children at increased risk for type 1 diabetes publication-title: Diabetes – volume: 29 start-page: 557 issue: 7 year: 2013 end-page: 567 article-title: Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY publication-title: Diabetes Metab Res Rev – volume: 39 start-page: 1535 issue: 9 year: 2016 end-page: 1542 article-title: Reversion of beta‐cell autoimmunity changes risk of type 1 diabetes: TEDDY study publication-title: Diabetes Care – volume: 8 start-page: 286 issue: 5 year: 2007 end-page: 298 article-title: The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design publication-title: Pediatr Diabetes – volume: 35 start-page: 797 issue: 6 year: 2012 end-page: 802 article-title: Spuriously high prevalence of prediabetes diagnosed by HbA(1c) in young Indians partly explained by hematological factors and iron deficiency anemia publication-title: Diabetes Care – volume: 12 start-page: 733 issue: 8 year: 2011 end-page: 743 article-title: The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants publication-title: Pediatric Diabetes – volume: 377 start-page: 301 issue: 3 year: 2017 article-title: Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012 publication-title: New Engl J Med – volume: 11 start-page: 5497 issue: 5 year: 2014 end-page: 5509 article-title: Elevated white blood cell count is associated with higher risk of glucose metabolism disorders in middle‐aged and elderly Chinese people publication-title: Int J Env Res Public Health – volume: 64 start-page: 1719 issue: 5 year: 2015 end-page: 1727 article-title: HbA1c predicts time to diagnosis of type 1 diabetes in children at risk publication-title: Diabetes – volume: 38 start-page: 1964 issue: 10 year: 2015 end-page: 1974 article-title: Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association publication-title: Diabetes Care – volume: 1150 start-page: 1 year: 2008 end-page: 13 article-title: The Environmental Determinants of Diabetes in the Young (TEDDY) study publication-title: Ann New York Acad Sci – volume: 3 issue: 18 year: 2018 article-title: Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes publication-title: JCI Insight – volume: 135 start-page: 395 issue: 3 year: 2006 end-page: 404 article-title: A detailed study of time‐dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence publication-title: Br J Haematol – volume: 7 start-page: 999 issue: 4 year: 2017 article-title: Glycated hemoglobin and red blood cell indices in non‐diabetic pregnant women publication-title: Clin Pract – volume: 18 start-page: 136 issue: 12 year: 2018 article-title: The Environmental Determinants of Diabetes in the Young (TEDDY) study: 2018 update publication-title: Curr Diab Rep – volume: 387 start-page: 2331 issue: 10035 year: 2016 end-page: 2339 article-title: Genetic risk factors for type 1 diabetes publication-title: Lancet – volume: 40 start-page: 1194 issue: 9 year: 2017 end-page: 1202 article-title: Genetic and environmental interactions modify the risk of diabetes‐related autoimmunity by 6 years of age: the TEDDY study publication-title: Diabetes Care – volume: 373 start-page: 2027 issue: 9680 year: 2009 end-page: 2033 article-title: Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study publication-title: Lancet (London, England) – volume: 413 start-page: 819 issue: 7‐8 year: 2012 end-page: 821 article-title: Effects of hemoglobin C, D, E, and S traits on measurements of HbA1c by six methods publication-title: Clin Chim Acta – volume: 25 start-page: 1865 issue: 12 year: 2019 end-page: 1872 article-title: Prospective virome analyses in young children at increased genetic risk for type 1 diabetes publication-title: Nat Med – volume: 57 start-page: 205 issue: 2 year: 2011 end-page: 214 article-title: Status of hemoglobin A1c measurement and goals for improvement: from chaos to order for improving diabetes care publication-title: Clin Chem – start-page: 701 year: 2011 – volume: 62 start-page: 2072 issue: 6 year: 2013 end-page: 2077 article-title: Reduction of circulating neutrophils precedes and accompanies type 1 diabetes publication-title: Diabetes – volume: 120 start-page: 89 year: 2016 end-page: 96 article-title: Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus publication-title: Diabetes Res Clin Pract – volume: 62 start-page: 1570 issue: 12 year: 2016 end-page: 1578 article-title: Impact of mean cell hemoglobin on Hb A1c‐defined glycemia status publication-title: Clin Chem – volume: 309 start-page: 2473 issue: 23 year: 2013 end-page: 2479 article-title: Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children publication-title: JAMA – volume: 18 start-page: 96 issue: 2 year: 2003 end-page: 117 article-title: Understanding the complete blood count with differential publication-title: J Perianesth Nurs – volume: 1173 start-page: 21 year: 2019 end-page: 32 article-title: Cellular iron metabolism and regulation publication-title: Adv Exp Med Biol – volume: 18 start-page: 794 issue: 8 year: 2017 end-page: 802 article-title: Residual beta‐cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls publication-title: Pediatr Diabetes – volume: 103 start-page: 3647 issue: 10 year: 2018 end-page: 3657 article-title: Youth with type 1 diabetes have adipose, hepatic, and peripheral insulin resistance publication-title: J Clin Endocr Metab – volume: 61 start-page: 1193 issue: 5 year: 2018 end-page: 1202 article-title: Coxsackievirus B1 infections are associated with the initiation of insulin‐driven autoimmunity that progresses to type 1 diabetes publication-title: Diabetologia – volume: 39 start-page: 1244 year: 1961 end-page: 1247 article-title: Enzymatic determination of glucose and fructose simultaneously publication-title: Klin Wochenschr – volume: 27S start-page: S129 year: 2019 end-page: S138 article-title: Cause or effect? A review of clinical data demonstrating beta cell dysfunction prior to the clinical onset of type 1 diabetes publication-title: Molec Metabol – volume: 24 start-page: 843 issue: 8 year: 2007 end-page: 847 article-title: Association of erythrocyte indices with glycated haemoglobin in pre‐menopausal women publication-title: Diabet Med – volume: 70 start-page: 1959 issue: 6 year: 1987 end-page: 1961 article-title: Coordinate glycosylation and cell surface expression of glycophorin A during normal human erythropoiesis publication-title: Blood – volume: 95 start-page: 3360 issue: 7 year: 2010 end-page: 3367 article-title: Harmonization of glutamic acid decarboxylase and islet antigen‐2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia publication-title: J Clin Endocrinol Metab – volume: 23 start-page: 301 issue: 2 year: 1968 end-page: 316 article-title: Evaluation of the hexokinase‐glucose‐6‐phosphate dehydrogenase method of determination of glucose in urine publication-title: Anal Biochem – volume: 44 start-page: 279 issue: 04 year: 2012 end-page: 285 article-title: Effects of erythropoietin on glucose metabolism publication-title: Horm Metab Res – ident: e_1_2_11_6_1 doi: 10.1007/s11892-018-1113-2 – ident: e_1_2_11_37_1 doi: 10.4081/cp.2017.999 – ident: e_1_2_11_34_1 doi: 10.1373/clinchem.2016.257659 – ident: e_1_2_11_4_1 doi: 10.1373/clinchem.2010.148221 – ident: e_1_2_11_5_1 doi: 10.1016/S0140-6736(16)30582-7 – ident: e_1_2_11_38_1 doi: 10.2337/dc15-1419 – ident: e_1_2_11_27_1 doi: 10.1007/978-981-13-9589-5_2 – ident: e_1_2_11_26_1 doi: 10.1111/j.1365-2141.2006.06279.x – ident: e_1_2_11_16_1 doi: 10.1210/jc.2010-0293 – ident: e_1_2_11_24_1 doi: 10.1210/jc.2018-00433 – ident: e_1_2_11_43_1 doi: 10.2337/db14-0497 – ident: e_1_2_11_18_1 doi: 10.1007/BF01506150 – ident: e_1_2_11_41_1 doi: 10.3390/ijerph110505497 – ident: e_1_2_11_29_1 doi: 10.2337/dc17-0238 – ident: e_1_2_11_28_1 doi: 10.1055/s-0032-1301901 – ident: e_1_2_11_17_1 doi: 10.1016/0003-2697(68)90361-8 – ident: e_1_2_11_33_1 doi: 10.2337/dc11-1321 – ident: e_1_2_11_31_1 doi: 10.1038/s41591-019-0667-0 – ident: e_1_2_11_44_1 doi: 10.1016/j.diabres.2016.07.027 – ident: e_1_2_11_25_1 doi: 10.1016/j.molmet.2019.06.010 – ident: e_1_2_11_7_1 doi: 10.1196/annals.1447.062 – ident: e_1_2_11_23_1 doi: 10.1053/jpan.2003.50013 – ident: e_1_2_11_20_1 doi: 10.1373/clinchem.2010.148841 – ident: e_1_2_11_32_1 doi: 10.1007/s00125-018-4561-y – ident: e_1_2_11_40_1 doi: 10.2337/diacare.27.2.491 – start-page: 701 volume-title: Applied Longitudinal Analysis year: 2011 ident: e_1_2_11_22_1 doi: 10.1002/9781119513469 – ident: e_1_2_11_15_1 doi: 10.1111/j.1751-553X.2007.00971.x – ident: e_1_2_11_30_1 doi: 10.1210/jc.2019-00421 – ident: e_1_2_11_36_1 doi: 10.1007/s00125-015-3599-3 – ident: e_1_2_11_10_1 doi: 10.2337/db18-0355 – ident: e_1_2_11_8_1 doi: 10.1001/jama.2013.6285 – ident: e_1_2_11_14_1 doi: 10.1002/dmrr.2427 – ident: e_1_2_11_3_1 doi: 10.1016/S0140-6736(09)60568-7 – ident: e_1_2_11_12_1 doi: 10.1111/j.1399-5448.2007.00269.x – ident: e_1_2_11_19_1 doi: 10.1111/pedi.12485 – ident: e_1_2_11_2_1 doi: 10.1056/NEJMc1706291 – ident: e_1_2_11_13_1 doi: 10.1111/j.1399-5448.2011.00774.x – ident: e_1_2_11_11_1 doi: 10.1172/jci.insight.122146 – ident: e_1_2_11_35_1 doi: 10.1111/j.1464-5491.2007.02161.x – ident: e_1_2_11_21_1 doi: 10.1016/j.cca.2011.12.019 – ident: e_1_2_11_9_1 doi: 10.2337/dc16-0181 – ident: e_1_2_11_39_1 doi: 10.1182/blood.V70.6.1959.1959 – ident: e_1_2_11_42_1 doi: 10.2337/db12-1345 |
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To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes... Islet beta cell autoantibody positive children with increased risk for developing type 1 diabetes have reduced red blood cell counts and parameters associated... To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are... ObjectivesTo investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes... Objectives: To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1... Abstract Objectives To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1... |
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| SubjectTerms | autoimmunity Blood tests Child Clinical Medicine Diabetes Diabetes Mellitus, Type 1 Endocrinology and Diabetes Endokrinologi och diabetes Erythrocyte Count Erythrocytes Genotype & phenotype Glucose glucose metabolism Glucose Tolerance Test Haplotypes HbA1c Health risk assessment Hemoglobin Humans Klinisk medicin Laboratories Medical and Health Sciences Medicin och hälsovetenskap Metabolism Neutrophils Original Original s Pathogenesis Population red blood cells Sweden type 1 diabetes United States |
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| Title | Complete blood counts with red blood cell determinants associate with reduced beta‐cell function in seroconverted Swedish TEDDY children |
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