Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus Calmette-Guérin

Background Diseases such as tuberculosis (TB) have always had a large impact on human health. Bacillus Calmette-Guérin (BCG) is used as a surrogate for TB during the development of anti-TB drugs. Nanoparticles (NPs) have attracted great interest in drug development. The purpose of this study was to...

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Vydané v:Journal of nanobiotechnology Ročník 10; číslo 1; s. 19
Hlavní autori: Zhou, Yan, Kong, Ying, Kundu, Subrata, Cirillo, Jeffrey D, Liang, Hong
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 06.05.2012
Springer Nature B.V
BMC
Predmet:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial effect
Antiinfectives and antibacterials
Bacillus
Bacteria
BCG
Biotechnology
Chemistry
Chemistry and Materials Science
Drug resistance
Drug therapy
Drugs
E coli
Escherichia coli
Escherichia coli - drug effects
Escherichia coli Infections - drug therapy
Gold
Gold - chemistry
Gold - pharmacology
Humans
Materials science
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Microbiology
Molecular Medicine
Molecular weight
Mycobacterium
Mycobacterium bovis - drug effects
Nanoparticle
Nanostructure
Nanotechnology
Particle Size
Silver
Silver - chemistry
Silver - pharmacology
Transmission electron microscopy
Tuberculosis
Tuberculosis - drug therapy
Tuberculosis - veterinary
Gold
Silver
Nanoparticle
Antibacterial effect
BCG
ISSN:1477-3155, 1477-3155
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Shrnutí:Background Diseases such as tuberculosis (TB) have always had a large impact on human health. Bacillus Calmette-Guérin (BCG) is used as a surrogate for TB during the development of anti-TB drugs. Nanoparticles (NPs) have attracted great interest in drug development. The purpose of this study was to examine the potential of NPs as anti-TB compounds by studying the interacting mechanisms between NPs and bacteria. Results We investigated effects of gold and silver NPs on BCG and Escherichia coli . Experimentally, particle size and shape were characterized using transmission electron microscopy (TEM). Different concentrations of NPs were applied in bacterial culture. The growth of E. coli was monitored through colony forming units (CFU). The mechanism of interaction between NPs and bacteria was analyzed through bacterial thin sections followed by TEM and scanning electron microscopy. Antibacterial effects on BCG were observed by recording fluorescent protein expression levels. Conclusions The results suggest NPs have potential applications as anti-TB compounds. The antibacterial effects and mechanism of action for NPs were dependent upon composition and surface modifications.
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ISSN:1477-3155
1477-3155
DOI:10.1186/1477-3155-10-19