Nasopharyngeal Pneumococcal Density during Asymptomatic Respiratory Virus Infection and Risk for Subsequent Acute Respiratory Illness

Increased nasopharyngeal pneumococcal (Streptococcus pneumoniae) colonization density has been associated with invasive pneumococcal disease, but factors that increase pneumococcal density are poorly understood. We evaluated pneumococcal densities in nasopharyngeal samples from asymptomatic young ch...

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Veröffentlicht in:Emerging infectious diseases Jg. 25; H. 11; S. 2040 - 2047
Hauptverfasser: Howard, Leigh M., Zhu, Yuwei, Griffin, Marie R., Edwards, Kathryn M., Williams, John V., Gil, Ana I., Vidal, Jorge E., Klugman, Keith P., Lanata, Claudio F., Grijalva, Carlos G.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States U.S. National Center for Infectious Diseases 01.11.2019
Centers for Disease Control and Prevention
Schlagworte:
acute respiratory illness
Asymptomatic Diseases
Child
Child, Preschool
Coinfection
Diagnosis
Female
Humans
Male
Nasopharyngeal Pneumococcal Density during Asymptomatic Respiratory Virus Infection and Risk for Subsequent Acute Respiratory Illness
Nasopharynx - microbiology
Pharmaceutical industry
pneumococcal colonization density
Pneumococcal Infections - epidemiology
Pneumococcal Infections - microbiology
Pneumococcal Infections - prevention & control
pneumococcus
Pneumonia
Public Health Surveillance
Respiratory tract diseases
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Risk Assessment
Risk Factors
Streptococcus pneumoniae
vaccine-preventable diseases
viral infection
Virus diseases
viruses
United States
acute respiratory illness
pneumococcus
viruses
viral infection
United States
children
pneumococcal colonization density
vaccine-preventable diseases
Peru
respiratory infections
Streptococcus pneumoniae
ISSN:1080-6040, 1080-6059, 1080-6059
Online-Zugang:Volltext
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Zusammenfassung:Increased nasopharyngeal pneumococcal (Streptococcus pneumoniae) colonization density has been associated with invasive pneumococcal disease, but factors that increase pneumococcal density are poorly understood. We evaluated pneumococcal densities in nasopharyngeal samples from asymptomatic young children from Peru and their association with subsequent acute respiratory illness (ARI). Total pneumococcal densities (encompassing all present serotypes) during asymptomatic periods were significantly higher when a respiratory virus was detected versus when no virus was detected (p<0.001). In adjusted analyses, increased pneumococcal density was significantly associated with the risk for a subsequent ARI (p<0.001), whereas asymptomatic viral detection alone was associated with lower risk for subsequent ARI. These findings suggest that interactions between viruses and pneumococci in the nasopharynx during asymptomatic periods might have a role in onset of subsequent ARI. The mechanisms for these interactions, along with other potentially associated host and environmental factors, and their role in ARI pathogenesis and pneumococcal transmission require further elucidation.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2511.190157