Nasopharyngeal Pneumococcal Density during Asymptomatic Respiratory Virus Infection and Risk for Subsequent Acute Respiratory Illness

Increased nasopharyngeal pneumococcal (Streptococcus pneumoniae) colonization density has been associated with invasive pneumococcal disease, but factors that increase pneumococcal density are poorly understood. We evaluated pneumococcal densities in nasopharyngeal samples from asymptomatic young ch...

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Vydané v:	Emerging infectious diseases Ročník 25; číslo 11; s. 2040 - 2047
Hlavní autori:	Howard, Leigh M., Zhu, Yuwei, Griffin, Marie R., Edwards, Kathryn M., Williams, John V., Gil, Ana I., Vidal, Jorge E., Klugman, Keith P., Lanata, Claudio F., Grijalva, Carlos G.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States U.S. National Center for Infectious Diseases 01.11.2019 Centers for Disease Control and Prevention
Predmet:	acute respiratory illness Asymptomatic Diseases Child Child, Preschool Coinfection Diagnosis Female Humans Male Nasopharyngeal Pneumococcal Density during Asymptomatic Respiratory Virus Infection and Risk for Subsequent Acute Respiratory Illness Nasopharynx - microbiology Pharmaceutical industry pneumococcal colonization density Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumococcal Infections - prevention & control pneumococcus Pneumonia Public Health Surveillance Respiratory tract diseases Respiratory Tract Infections - epidemiology Respiratory Tract Infections - virology Risk Assessment Risk Factors Streptococcus pneumoniae vaccine-preventable diseases viral infection Virus diseases viruses United States acute respiratory illness pneumococcus viruses viral infection United States children pneumococcal colonization density vaccine-preventable diseases Peru respiratory infections Streptococcus pneumoniae
ISSN:	1080-6040, 1080-6059, 1080-6059
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Shrnutí:	Increased nasopharyngeal pneumococcal (Streptococcus pneumoniae) colonization density has been associated with invasive pneumococcal disease, but factors that increase pneumococcal density are poorly understood. We evaluated pneumococcal densities in nasopharyngeal samples from asymptomatic young children from Peru and their association with subsequent acute respiratory illness (ARI). Total pneumococcal densities (encompassing all present serotypes) during asymptomatic periods were significantly higher when a respiratory virus was detected versus when no virus was detected (p<0.001). In adjusted analyses, increased pneumococcal density was significantly associated with the risk for a subsequent ARI (p<0.001), whereas asymptomatic viral detection alone was associated with lower risk for subsequent ARI. These findings suggest that interactions between viruses and pneumococci in the nasopharynx during asymptomatic periods might have a role in onset of subsequent ARI. The mechanisms for these interactions, along with other potentially associated host and environmental factors, and their role in ARI pathogenesis and pneumococcal transmission require further elucidation.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1080-6040 1080-6059 1080-6059
DOI:	10.3201/eid2511.190157