Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease

Background and aims Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated the dynamics of gene expression and DNA methylation in blood samples of...

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Bibliographic Details
Published in:	Genome medicine Vol. 14; no. 1; pp. 1 - 20
Main Authors:	Mishra, Neha, Aden, Konrad, Blase, Johanna I., Baran, Nathan, Bordoni, Dora, Tran, Florian, Conrad, Claudio, Avalos, Diana, Jaeckel, Charlot, Scherer, Michael, Sørensen, Signe B., Overgaard, Silja H., Schulte, Berenice, Nikolaus, Susanna, Rey, Guillaume, Gasparoni, Gilles, Lyons, Paul A., Schultze, Joachim L., Walter, Jörn, Andersen, Vibeke, Dermitzakis, Emmanouil T., Schreiber, Stefan, Rosenstiel, Philip
Format:	Journal Article
Language:	English
Published:	London BioMed Central 24.09.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adalimumab Analysis Antagonists Bioinformatics Biological analysis Biologics Biomarker Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Disease DNA methylation DNA sequencing Erythropoiesis Ethylenediaminetetraacetic acid Gastrointestinal diseases Gene expression Genes Genetics Genetics & genetic processes Genetics (clinical) Genomes Genomics Génétique & processus génétiques Human Genetics Humans Inflammatory bowel disease Inflammatory Bowel Diseases Inflammatory Bowel Diseases/drug therapy Inflammatory Bowel Diseases/genetics Infliximab Infliximab/therapeutic use Interferon Interferons Interferons/therapeutic use Intestinal inflammation Leukocytes (eosinophilic) Life sciences Lymphocytes T Machine learning Medical research Medicine, Experimental Medicine/Public Health Metabolomics Methylation Molecular Biology Molecular Medicine Monoclonal antibodies Olig2 protein Patients Personalized medicine Platelet aggregation Prospective Studies Remission Remission (Medicine) RNA Sciences du vivant Systems Biology Therapy response Transcriptomics Tumor necrosis factor Tumor Necrosis Factor Inhibitors Tumor Necrosis Factor-alpha Tumor necrosis factor-TNF Tumor necrosis factor-α Intestinal inflammation Biomarker Therapy response Personalized medicine Biologics
ISSN:	1756-994X, 1756-994X
Online Access:	Get full text
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