A pH-Driven and photoresponsive nanocarrier: Remotely-controlled by near-infrared light for stepwise antitumor treatment

The hollow gold nanospheres (HAuNS) have shown medicinal promise due to their inert and nontoxic properties with unique photothermal therapy capabilities. In this study, the electrostatic approach was employed to successfully absorb Chlorin e6 (Ce6) simultaneously with the pH (low) insertion peptide...

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Bibliographic Details
Published in:Biomaterials Vol. 79; pp. 25 - 35
Main Authors: Yu, Meng, Guo, Fang, Wang, Jinping, Tan, Fengping, Li, Nan
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.02.2016
Subjects:
Ablation
absorption
Advanced Basic Science
Cell Survival - drug effects
Cell Survival - radiation effects
chlorins
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - chemistry
Delayed-Action Preparations - radiation effects
Delivery systems
Dentistry
Diffusion - radiation effects
electrostatic interactions
Electrostatics
fever
gold
Gold - chemistry
Gold - therapeutic use
HeLa Cells
Humans
Hydrogen-Ion Concentration
Insertion
irradiation
ligands
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Nanocapsules - administration & dosage
Nanocapsules - chemistry
Nanocapsules - radiation effects
nanocarriers
nanogold
nanospheres
Nanostructure
neoplasm cells
Patients
Peptides
pH-driven
photochemotherapy
Photochemotherapy - methods
Photoresponsive
photosensitizing agents
Photosensitizing Agents - administration & dosage
Porphyrins - administration & dosage
PTT/PDT effect
Single light trigger
Stepwise therapy
Therapy
Treatment Outcome
Photoresponsive
Single light trigger
pH-driven
PTT/PDT effect
Stepwise therapy
ISSN:0142-9612, 1878-5905, 1878-5905
Online Access:Get full text
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Summary:The hollow gold nanospheres (HAuNS) have shown medicinal promise due to their inert and nontoxic properties with unique photothermal therapy capabilities. In this study, the electrostatic approach was employed to successfully absorb Chlorin e6 (Ce6) simultaneously with the pH (low) insertion peptide (pHLIP) onto surface of HAuNS, forming HAuNS-pHLIP-Ce6 with desirable pH-driven and NIR light-stimulated controlled therapeutical effect. The HAuNS-pHLIP-Ce6 experienced hyperthermia within 5 min of laser exposure, which marked the photothermal therapy (PTT) and deduced the agents release due to the reduction of electrostatic interaction. The improved strategy facilitated a stepwise photoresponsive system capable of active accumulation and retention effects, photothermal ablation of tumor cells, release of photosensitizers (PS), and subsequently photodynamic therapy (PDT) in a single light irradiation session. The smart delivery system had been proved with multi-functionalities via conjugated targeting ligand and PS. The external absorption of patient tailored medication combinations was also possible with this treatment platform. [Display omitted]
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ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2015.11.049