Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis

Chronic infections with herpes simplex virus (HSV) type 1 are highly prevalent in populations worldwide and cause recurrent oral lesions in up to 40% of infected subjects. We investigated the antiviral activity of a defined Spirulina platensis microalga extract and of purified calcium spirulan (Ca-S...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 137; no. 1; pp. 197 - 203.e3
Main Authors:	Mader, Julia, Gallo, Antonio, Schommartz, Tim, Handke, Wiebke, Nagel, Claus-Henning, Günther, Patrick, Brune, Wolfram, Reich, Kristian
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2016 Elsevier Limited
Subjects:	Adult Aged Algae Allergy and Immunology Animals Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Calcium calcium spirulan Cell Line Cercopithecus aethiops Cosmetics Epithelial Cells - drug effects Epithelial Cells - virology Female herpes labialis Herpes Labialis - prevention & control Herpes simplex virus 1 Herpes viruses Herpesvirus Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - pathogenicity Herpesvirus 1, Human - physiology Herpesvirus 8, Human - drug effects Herpesvirus 8, Human - pathogenicity Herpesvirus 8, Human - physiology Humans Infections Kaposi sarcoma Kaposi sarcoma–associated herpesvirus/human herpes virus 8 keratinocytes Keratinocytes - drug effects Keratinocytes - virology Methods Middle Aged Polysaccharides - pharmacology Polysaccharides - therapeutic use Spirulina Spirulina microalgae Spirulina platensis Vero Cells Viral infections Virus Attachment - drug effects Young Adult Germany KSHV/HHV-8 MOI HSV keratinocytes TCID50 herpes labialis Ca-SP Herpes simplex virus 1 Kaposi sarcoma CHX SPME ACV Spirulina microalgae calcium spirulan IC50 PMU Kaposi sarcoma–associated herpesvirus/human herpes virus 8 pfu PRA IC 50 Plaque-forming units Herpes simplex virus Half-maximal inhibitory concentration Plaque reduction assay 50% Tissue culture infective dose Multiplicity of infection Acyclovir Permanent lip makeup Cycloheximide TCID 50 Spirulina platensis microalgae extract
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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