MMP-9 triggered self-assembly of doxorubicin nanofiber depots halts tumor growth

A central challenge in cancer care is to ensure that therapeutic compounds reach their targets. One approach is to use enzyme-responsive biomaterials, which reconfigure in response to endogenous enzymes that are overexpressed in diseased tissues, as potential site-specific anti-tumoral therapies. He...

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Bibliographic Details
Published in:	Biomaterials Vol. 98; pp. 192 - 202
Main Authors:	Kalafatovic, Daniela, Nobis, Max, Son, Jiye, Anderson, Kurt I., Ulijn, Rein V.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.08.2016
Subjects:	Advanced Basic Science animal models Animals biocompatible materials Biomaterials Biomedical materials Cancer therapy Cell Line, Tumor Cell Proliferation - drug effects Dentistry Doxorubicin Doxorubicin - pharmacology Doxorubicin - therapeutic use Drug Carriers - chemistry Enzymes Humans hydrolysis Matrix Metalloproteinase 9 - metabolism Mice, Nude Micelles MMP Morphology transition nanofibers Nanofibers - chemistry Nanofibers - ultrastructure Nanostructure Neoplasm Invasiveness neoplasms Neoplasms - drug therapy Neoplasms - pathology Peptides Peptides - pharmacology Self assembly Surgical implants tissues Tumors MMP Self-assembly Peptides Morphology transition Cancer therapy
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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