Physiological significance of antithrombin D-helix interaction with vascular GAGs

•Interaction of D-helix of AT with therapeutic heparins promotes the protease-inhibitory function of the serpin.•Interaction of D-helix of AT with vascular GAGs unveils the anti-inflammatory signaling function of the serpin. [Display omitted] Antithrombin (AT) is an anticoagulant serpin involved in...

Full description

Bibliographic Details

Published in:	Blood advances Vol. 9; no. 5; pp. 966 - 978
Main Authors:	Biswas, Indranil, Panicker, Sumith R., Lupu, Florea, Rezaie, Alireza R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 11.03.2025 The American Society of Hematology Elsevier
Subjects:	Animals Antithrombins - chemistry Antithrombins - metabolism Glycosaminoglycans - metabolism Hematology Humans Mice Mutation Protein Binding Vascular Biology
ISSN:	2473-9529, 2473-9537, 2473-9537
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!