2022 Update on Prostate Cancer Epidemiology and Risk Factors—A Systematic Review

Prostate cancer remains the second most common cancer among men. Screening is gaining acceptance, likely reducing mortality at the cost of overdiagnosis and overtreatment. Increasing use of magnetic resonance imaging and biomarkers may mitigate some of the negative consequences of screening. Prostat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European urology Jg. 84; H. 2; S. 191 - 206
Hauptverfasser: Bergengren, Oskar, Pekala, Kelly R., Matsoukas, Konstantina, Fainberg, Jonathan, Mungovan, Sean F., Bratt, Ola, Bray, Freddie, Brawley, Otis, Luckenbaugh, Amy N., Mucci, Lorelei, Morgan, Todd M., Carlsson, Sigrid V.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Elsevier B.V 01.08.2023
Schlagworte:
Epidemiology
Humans
Male
Nephrology
Njurmedicin
Prostate - pathology
Prostate cancer
Prostate-Specific Antigen
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - pathology
Retrospective Studies
Risk Factors
Screening
Screening
Prostate cancer
Epidemiology
Risk factors
ISSN:0302-2838, 1873-7560, 1873-7560
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Prostate cancer remains the second most common cancer among men. Screening is gaining acceptance, likely reducing mortality at the cost of overdiagnosis and overtreatment. Increasing use of magnetic resonance imaging and biomarkers may mitigate some of the negative consequences of screening. Prostate cancer (PCa) is one of the most common cancers worldwide. Understanding the epidemiology and risk factors of the disease is paramount to improve primary and secondary prevention strategies. To systematically review and summarize the current evidence on the descriptive epidemiology, large screening studies, diagnostic techniques, and risk factors of PCa. PCa incidence and mortality rates for 2020 were obtained from the GLOBOCAN database of the International Agency for Research on Cancer. A systematic search was performed in July 2022 using PubMed/MEDLINE and EMBASE biomedical databases. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines and was registered in PROSPERO (CRD42022359728). Globally, PCa is the second most common cancer, with the highest incidence in North and South America, Europe, Australia, and the Caribbean. Risk factors include age, family history, and genetic predisposition. Additional factors may include smoking, diet, physical activity, specific medications, and occupational factors. As PCa screening has become more accepted, newer approaches such as magnetic resonance imaging (MRI) and biomarkers have been implemented to identify patients who are likely to harbor significant tumors. Limitations of this review include the evidence being derived from meta-analyses of mostly retrospective studies. PCa remains the second most common cancer among men worldwide. PCa screening is gaining acceptance and will likely reduce PCa mortality at the cost of overdiagnosis and overtreatment. Increasing use of MRI and biomarkers for the detection of PCa may mitigate some of the negative consequences of screening. Prostate cancer (PCa) remains the second most common cancer among men, and screening for PCa is likely to increase in the future. Improved diagnostic techniques can help reduce the number of men who need to be diagnosed and treated to save one life. Avoidable risk factors for PCa may include factors such as smoking, diet, physical activity, specific medications, and certain occupations.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
ObjectType-Review-4
content type line 23
Supervision: Morgan, Carlsson.
Other: None.
Author contributions: Oskar Bergengren had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Critical revision of the manuscript for important intellectual content: Bergengren, Pekala, Matsoukas, Fainberg, Mungovan, Bratt, Bray, Brawley, Luckenbaugh, Mucci, BT, Morgan, Carlsson.
Statistical analysis: None.
Study concept and design: Bergengren, Matsoukas, Morgan, Carlsson.
Administrative, technical, or material support: Matsoukas.
Obtaining funding: None.
Acquisition of data: Bergengren, Pekala, Matsoukas, Fainberg, Mungovan, Bratt, Bray, Brawley, Luckenbaugh, BT, Morgan, Carlsson.
Drafting of the manuscript: Bergengren, Pekala.
Analysis and interpretation of data: Bergengren, Pekala, Matsoukas, Fainberg, Mungovan, Bratt, Bray, Brawley, Luckenbaugh, BT, Morgan, Carlsson.
ISSN:0302-2838
1873-7560
1873-7560
DOI:10.1016/j.eururo.2023.04.021