NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

Background The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in tumor cells and promotes tumor cell survival after radiation-induced DNA damage. Because the pathway may not be completely inhibited after blockade of PI3K itself, due to feedback through mammalian target of rapamycin (m...

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Vydané v:	Radiation oncology (London, England) Ročník 7; číslo 1; s. 48
Hlavní autori:	Fokas, Emmanouil, Yoshimura, Michio, Prevo, Remko, Higgins, Geoff, Hackl, Wolfgang, Maira, Sauveur-Michel, Bernhard, Eric J, McKenna, WGillies, Muschel, Ruth J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 27.03.2012 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Analysis Biomedical and Life Sciences Biomedicine Cancer Cancer cells Cancer Research Cell Line, Tumor Endothelial cells Endothelial Cells - drug effects Enzyme inhibitors Enzymes Human Umbilical Vein Endothelial Cells - drug effects Humans Imaging Imidazoles - pharmacology Kinases Medical research mTOR Mutation Oncology Phosphoinositide-3 Kinase Inhibitors Physiological aspects PI3K Quinolines - pharmacology Radiation-Sensitizing Agents - pharmacology Radiology Radiosensitization Radiotherapy Rodents TOR Serine-Threonine Kinases - antagonists & inhibitors Vascular endothelial growth factor VEGF mTOR Radiosensitization PI3K VEGF Endothelial cells
ISSN:	1748-717X, 1748-717X
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