Mapping the epigenetic modifications of DNA and RNA

Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biologica...

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Vydané v:	Protein & cell Ročník 11; číslo 11; s. 792 - 808
Hlavní autori:	Zhao, Lin-Yong, Song, Jinghui, Liu, Yibin, Song, Chun-Xiao, Yi, Chengqi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Beijing Higher Education Press 01.11.2020 Springer Nature B.V Oxford University Press
Predmet:	Animals Biochemistry Biomedical and Life Sciences Cell Biology Deoxyribonucleic acid Developmental Biology DNA DNA - genetics DNA - metabolism DNA Methylation DNA modification DNA sequencing Epigenesis, Genetic Epigenetics Epigenomics epitranscriptomics Gene expression Gene mapping Genomes Human Genetics Humans Life Sciences long read sequencing Protein Science Review RNA - genetics RNA - metabolism RNA modification Stem Cells Transcriptome DNA methylation RNA modification DNA modification long read sequencing epitranscriptomics epigenetics
ISSN:	1674-800X, 1674-8018, 1674-8018
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Popis
Shrnutí:	Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study. Here, we review the recent technological advances in this rapidly evolving field. We focus on high-throughput detection methods and biological findings for these modifications, and discuss questions to be addressed as well. We also summarize third-generation sequencing methods, which enable long-read and single-molecule sequencing of DNA and RNA modification.
Bibliografia:	RNA modification long read sequencing epitranscriptomics DNA methylation Document received on :2020-02-12 DNA modification Document accepted on :2020-03-16 epigenetics ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1674-800X 1674-8018 1674-8018
DOI:	10.1007/s13238-020-00733-7