Mapping the epigenetic modifications of DNA and RNA

Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biologica...

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Bibliographic Details
Published in:Protein & cell Vol. 11; no. 11; pp. 792 - 808
Main Authors: Zhao, Lin-Yong, Song, Jinghui, Liu, Yibin, Song, Chun-Xiao, Yi, Chengqi
Format: Journal Article
Language:English
Published: Beijing Higher Education Press 01.11.2020
Springer Nature B.V
Oxford University Press
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Cell Biology
Deoxyribonucleic acid
Developmental Biology
DNA
DNA - genetics
DNA - metabolism
DNA Methylation
DNA modification
DNA sequencing
Epigenesis, Genetic
Epigenetics
Epigenomics
epitranscriptomics
Gene expression
Gene mapping
Genomes
Human Genetics
Humans
Life Sciences
long read sequencing
Protein Science
Review
RNA - genetics
RNA - metabolism
RNA modification
Stem Cells
Transcriptome
DNA methylation
RNA modification
DNA modification
long read sequencing
epitranscriptomics
epigenetics
ISSN:1674-800X, 1674-8018, 1674-8018
Online Access:Get full text
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Description
Summary:Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study. Here, we review the recent technological advances in this rapidly evolving field. We focus on high-throughput detection methods and biological findings for these modifications, and discuss questions to be addressed as well. We also summarize third-generation sequencing methods, which enable long-read and single-molecule sequencing of DNA and RNA modification.
Bibliography:RNA modification
long read sequencing
epitranscriptomics
DNA methylation
Document received on :2020-02-12
DNA modification
Document accepted on :2020-03-16
epigenetics
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ISSN:1674-800X
1674-8018
1674-8018
DOI:10.1007/s13238-020-00733-7