Molecular, serological and in vitro culture-based characterization of Bourbon virus, a newly described human pathogen of the genus Thogotovirus

•Full-genomic analyses indicate that BRBV is a distinct member of the genus Thogotovirus.•Serological characterization further indicates that BRBV is a distinct member of the genus Thogotovirus.•Growth of BRBV in cell culture suggests association with tick and mammalian hosts.•Preliminary evaluation...

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Bibliographic Details
Published in:	Journal of clinical virology Vol. 73; pp. 127 - 132
Main Authors:	Lambert, Amy J., Velez, Jason O., Brault, Aaron C., Calvert, Amanda E., Bell-Sakyi, Lesley, Bosco-Lauth, Angela M., Staples, J. Erin, Kosoy, Olga I.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2015
Subjects:	Allergy and Immunology Animals Bourbon virus Cell Line Characterization Chlorocebus aethiops Disease Models, Animal Genome, Viral HeLa Cells Humans In vitro growth Infectious Disease Influenza, Human - immunology Influenza, Human - virology Ixodidae Male Mice Molecular Orthomyxovirus Phylogeny Serological Thogotovirus Thogotovirus - classification Thogotovirus - genetics Thogotovirus - isolation & purification Vero Cells Viral Load ORF Bourbon virus HTS MOI IP Molecular PRNT Characterization In vitro growth CDS RT-PCR Serological IC BRBV NJ DPI Thogotovirus PFU open reading frame intracranial days post onset multiplicity of infection Centers for Disease Control and Prevention plaque reduction neutralization test high throughput sequencing neighbor joining intraperitoneal plaque forming unit reverse transcription polymerase chain reaction
ISSN:	1386-6532, 1873-5967, 1873-5967
Online Access:	Get full text
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