Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy

Natural compounds derived from marine organisms have shown a wide variety of anti-tumor effects and a lot of attention has been drawn to further development of the isolated compounds. A vast quantity of individual chemical structures from different organisms has shown a variety of apoptosis inducing...

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Vydáno v:	Cancer letters Ročník 332; číslo 2; s. 295 - 303
Hlavní autoři:	von Schwarzenberg, Karin, Vollmar, Angelika M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Ireland Elsevier Ireland Ltd 28.05.2013 Elsevier Limited
Témata:	Alkaloids Alkaloids - pharmacology Alkanes Alkanes - pharmacology Animals Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Antineoplastic Agents Antineoplastic Agents - pharmacology Apoptosis Aquatic Organisms Aquatic Organisms - chemistry Biological Products Biological Products - pharmacology Bryostatins Bryostatins - pharmacology Cancer Cancer therapies Carbamates Carbamates - pharmacology caspases cell growth Cell Proliferation chemical structure chemistry Depsipeptides Depsipeptides - pharmacology Dioxoles Dioxoles - pharmacology Drug Screening Assays, Antitumor Hematology, Oncology and Palliative Medicine Humans Kinases Lactones Lactones - pharmacology Macrolides Macrolides - pharmacology Marine compounds mechanism of action metabolism Microtubules Microtubules - metabolism Models, Chemical Natural compounds Neoplasms Neoplasms - metabolism Neoplasms - pathology pathology pharmacology Phenanthrolines Phenanthrolines - pharmacology Phenazines Phenazines - pharmacology proteasome endopeptidase complex Proteasome Endopeptidase Complex - metabolism Pyrones Pyrones - pharmacology Pyrroles Pyrroles - pharmacology Quinolines Quinolines - pharmacology Spiro Compounds Spiro Compounds - pharmacology Steroids Steroids - pharmacology Tetrahydroisoquinolines Tetrahydroisoquinolines - pharmacology therapeutics Thiazoles Thiazoles - pharmacology Trabectedin Natural compounds Marine compounds Cancer Apoptosis
ISSN:	0304-3835, 1872-7980, 1872-7980
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Natural compounds derived from marine organisms have shown a wide variety of anti-tumor effects and a lot of attention has been drawn to further development of the isolated compounds. A vast quantity of individual chemical structures from different organisms has shown a variety of apoptosis inducing mechanisms in a variety of tumor cells. The bis-steroidal cephalostatin 1 for example, induces apoptosis via activation of caspases whereas the polyketide discodermolide inhibits cell growth by binding to and stabilizing microtubule and salisporamide A, the product of an actinobacterial strain, is an inhibitor of the proteasome. This great variety of mechanisms of action can help to overcome the multitude of resistances exhibited by different tumor specimens. Products from marine organisms and their synthetic derivates are therefore an important source for new therapeutics for single agent or combined therapy with other chemotherapeutics to support the struggle against cancer.
Bibliografie:	http://dx.doi.org/10.1016/j.canlet.2010.07.004 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0304-3835 1872-7980 1872-7980
DOI:	10.1016/j.canlet.2010.07.004