Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy

Natural compounds derived from marine organisms have shown a wide variety of anti-tumor effects and a lot of attention has been drawn to further development of the isolated compounds. A vast quantity of individual chemical structures from different organisms has shown a variety of apoptosis inducing...

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Bibliographic Details
Published in:Cancer letters Vol. 332; no. 2; pp. 295 - 303
Main Authors: von Schwarzenberg, Karin, Vollmar, Angelika M.
Format: Journal Article
Language:English
Published: Ireland Elsevier Ireland Ltd 28.05.2013
Elsevier Limited
Subjects:
Alkaloids
Alkaloids - pharmacology
Alkanes
Alkanes - pharmacology
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents
Antineoplastic Agents - pharmacology
Apoptosis
Aquatic Organisms
Aquatic Organisms - chemistry
Biological Products
Biological Products - pharmacology
Bryostatins
Bryostatins - pharmacology
Cancer
Cancer therapies
Carbamates
Carbamates - pharmacology
caspases
cell growth
Cell Proliferation
chemical structure
chemistry
Depsipeptides
Depsipeptides - pharmacology
Dioxoles
Dioxoles - pharmacology
Drug Screening Assays, Antitumor
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Lactones
Lactones - pharmacology
Macrolides
Macrolides - pharmacology
Marine compounds
mechanism of action
metabolism
Microtubules
Microtubules - metabolism
Models, Chemical
Natural compounds
Neoplasms
Neoplasms - metabolism
Neoplasms - pathology
pathology
pharmacology
Phenanthrolines
Phenanthrolines - pharmacology
Phenazines
Phenazines - pharmacology
proteasome endopeptidase complex
Proteasome Endopeptidase Complex - metabolism
Pyrones
Pyrones - pharmacology
Pyrroles
Pyrroles - pharmacology
Quinolines
Quinolines - pharmacology
Spiro Compounds
Spiro Compounds - pharmacology
Steroids
Steroids - pharmacology
Tetrahydroisoquinolines
Tetrahydroisoquinolines - pharmacology
therapeutics
Thiazoles
Thiazoles - pharmacology
Trabectedin
Natural compounds
Marine compounds
Cancer
Apoptosis
ISSN:0304-3835, 1872-7980, 1872-7980
Online Access:Get full text
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Summary:Natural compounds derived from marine organisms have shown a wide variety of anti-tumor effects and a lot of attention has been drawn to further development of the isolated compounds. A vast quantity of individual chemical structures from different organisms has shown a variety of apoptosis inducing mechanisms in a variety of tumor cells. The bis-steroidal cephalostatin 1 for example, induces apoptosis via activation of caspases whereas the polyketide discodermolide inhibits cell growth by binding to and stabilizing microtubule and salisporamide A, the product of an actinobacterial strain, is an inhibitor of the proteasome. This great variety of mechanisms of action can help to overcome the multitude of resistances exhibited by different tumor specimens. Products from marine organisms and their synthetic derivates are therefore an important source for new therapeutics for single agent or combined therapy with other chemotherapeutics to support the struggle against cancer.
Bibliography:http://dx.doi.org/10.1016/j.canlet.2010.07.004
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ISSN:0304-3835
1872-7980
1872-7980
DOI:10.1016/j.canlet.2010.07.004