Phylogenetic Relationships of Southern African West Nile Virus Isolates

Phylogenetic relationships were examined for 29 southern African West Nile virus (formal name West Nile virus [WNV]) isolates from various sources in four countries from 1958 to 2001. In addition, sequence data were retrieved from GenBank for another 23 WNV isolates and Kunjin and Japanese encephali...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 8; no. 8; pp. 820 - 826
Main Authors: Burt, Felicity J., Grobbelaar, Antoinette A., Leman, Patricia A., Anthony, Fiona S., Gibson, Georgina V.F., Swanepoel, Robert
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.08.2002
Centers for Disease Control and Prevention
Subjects:
Aedes - virology
Africa, Southern
Animals
Birds - virology
Cladistic analysis
Culex - virology
Distribution
Dogs
Evolution, Molecular
Genetic aspects
Horses - virology
Humans
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction
South Africa
Virus diseases
West Nile fever
West Nile Fever - virology
West Nile virus - genetics
West Nile virus - isolation & purification
Africa, Southern
South Africa
ISSN:1080-6040, 1080-6059
Online Access:Get full text
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Summary:Phylogenetic relationships were examined for 29 southern African West Nile virus (formal name West Nile virus [WNV]) isolates from various sources in four countries from 1958 to 2001. In addition, sequence data were retrieved from GenBank for another 23 WNV isolates and Kunjin and Japanese encephalitis viruses. All isolates belonged to two lineages. Lineage 1 isolates were from central and North Africa, Europe, Israel, and North America; lineage 2 isolates were from central and southern Africa and Madagascar. No strict correlation existed between grouping and source of virus isolate, pathogenicity, geographic distribution, or year of isolation. Some southern African isolates have been associated with encephalitis in a human, a horse, and a dog and with fatal hepatitis in a human and death of an ostrich chick.
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ISSN:1080-6040
1080-6059
DOI:10.3201/eid0808.020027