The exerkine apelin reverses age-associated sarcopenia

Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition often responsible for the medical institutionalization of elderly individuals. Herein we report that production...

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Veröffentlicht in:	Nature Medicine Jg. 24; H. 9; S. 1360 - 1371
Hauptverfasser:	Vinel, Claire, Lukjanenko, Laura, Batut, Aurelie, Deleruyelle, Simon, Pradère, Jean-Philippe, Le Gonidec, Sophie, Dortignac, Alizée, Geoffre, Nancy, Pereira, Ophelie, Karaz, Sonia, Lee, Umji, Camus, Mylène, Chaoui, Karima, Mouisel, Etienne, Bigot, Anne, Mouly, Vincent, Vigneau, Mathieu, Pagano, Allan F., Chopard, Angèle, Pillard, Fabien, Guyonnet, Sophie, Cesari, Matteo, Burlet-Schiltz, Odile, Pahor, Marco, Feige, Jerome N., Vellas, Bruno, Valet, Philippe, Dray, Cedric
Format:	Journal Article Magazine Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.09.2018 Nature Publishing Group
Schlagworte:	631/443/7 692/308/575 692/53 692/698/1671/1668/1973 Adenylate Kinase - metabolism Adolescent Adult Age Aged Aged, 80 and over Aging Aging - pathology Animals Apelin - biosynthesis Apelin - blood Apelin Receptors - deficiency Apelin Receptors - metabolism Autonomy Autophagy Biomedical and Life Sciences Biomedicine Body Weight Cancer Research Cholecystokinin Diagnostic software Diagnostic systems Exercise Geriatrics Gerontology Hormones Humans Infectious Diseases Inflammation Kinetics Life Sciences Medical innovations Metabolic Diseases Mice, Inbred C57BL Molecular Medicine Muscle Cells - metabolism Muscle contraction Muscle function Muscle weakness Muscle Weakness - drug therapy Muscle Weakness - pathology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscles Neurosciences Older people Organelle Biogenesis Osteoporosis Peptides Phagocytosis Pharmacology Physical activity Protein Biosynthesis Proto-Oncogene Proteins c-akt - metabolism Recombinant proteins Regeneration Ribosomal Protein S6 Kinases, 70-kDa - metabolism Rodents Sarcopenia Sarcopenia - blood Sarcopenia - pathology Satellite Cells, Skeletal Muscle - metabolism Skeletal muscle Stem cell transplantation Stem cells Testosterone France adipose tissue regenerative capacity skeletal muscle physical activity satellite cells
ISSN:	1078-8956, 1546-170X, 1546-170X, 1744-7933
Online-Zugang:	Volltext
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