Cladograms with Path to Event (ClaPTE): A novel algorithm to detect associations between genotypes or phenotypes using phylogenies

Associations between genotype and phenotype provide insight into the evolution of pathogenesis, drug resistance, and the spread of pathogens between hosts. However, common ancestry can lead to apparent associations between biologically unrelated features. The novel method Cladograms with Path to Eve...

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Bibliographic Details
Published in:	Computers in biology and medicine Vol. 58; pp. 1 - 13
Main Authors:	Handelman, Samuel K, Aaronson, Jacob M., Seweryn, Michal, Voronkin, Igor, Kwiek, Jesse J., Sadee, Wolfgang, Verducci, Joseph S., Janies, Daniel A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01.03.2015 Elsevier Limited
Subjects:	Algorithms Computational Biology - methods Correlated evolution Drug resistance E coli Evolution, Molecular Experiments Genealogy Genetic simulation Genotype Genotype & phenotype Genotype-phenotype association HIV evolution Human immunodeficiency virus Hypotheses Influenza Influenza A Virus, H1N1 Subtype - genetics Influenza evolution Internal Medicine Methods Models, Genetic Mutation Other Phenotype Phylogenetics Phylogeny Protein evolution Proteins Proteins - genetics Studies Trees Protein evolution FIC HIV evolution Correlated evolution Fig. or Figs Drug resistance Genetic simulation PCA R.O.C Influenza evolution Eq. or Eqs Phylogenetics ClaPTE Genotype-phenotype association Figure or Figures principal components analysis Felsenstein’s independent contrasts Cladogram with Path to Event Equation or Equations receiver operating characteristic
ISSN:	0010-4825, 1879-0534, 1879-0534
Online Access:	Get full text
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